| 阿片类前体药物的研究进展 |
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| 引用本文： | 李炜,章承继,仇缀百. 阿片类前体药物的研究进展[J]. 中国药物化学杂志, 2004, 14(1): 51-55,64 |
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| 作者姓名： | 李炜 章承继 仇缀百 |
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| 作者单位： | 复旦大学药学院药物化学教研室,上海,200032 |
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| 摘 要： | 从提高代谢稳定性、膜通透性、延长作用时效、定位于脑内的化学传递系统、去除苦味、减少血浆蛋白结合率等6个方面介绍了近年来国内外有关阿片类前体药物的应用,对现有镇痛药物的研究和开发有一定的参考价值.
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| 关 键 词： | 药物化学 制备 综述 阿片受体 配基 镇痛药物 前体药物 |
| 文章编号： | 1005-0108(2004)01-0051-05 |
Progress of research on opiate prodrugs |
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| LI Wei,ZHANG Cheng-ji,QIU Zhui-bai. Progress of research on opiate prodrugs[J]. Chinese Journal of Medicinal Chemistry, 2004, 14(1): 51-55,64 |
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| Authors: | LI Wei ZHANG Cheng-ji QIU Zhui-bai |
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| Abstract: | Recent advances in the study on the prodrugs of opioids were reviewed,including metabolic stability,membrane permeation,duration of effect,chemical delivery system on brain targeting,bitterness removal,the reduction of plasma protein binding ability.It may have some values in the drug research and development based on the current use in analgesics. |
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| Keywords: | medicinal chemistry preparation review opioid receptor ligands analgesics prodrug |
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