中国女性乳腺癌危险因素的Meta分析

目的]评价中国女性乳腺癌部分危险因素的作用，探讨乳腺癌的病因。方法]运用Meta分析方法对我国1996～2006年间公开发表的有关乳腺癌危险因素病例对照研究的12篇文献资料进行定量综合分析。结果]各因素合并OR值分别为：初潮年龄OR=1．5401（95％CI：1．3437～1．7654）；哺乳OR=0．6837（95％CI：0．4779—0．9782）；口服避孕药OR=1．3278（95％CI：1．0627—1．6589）；良性乳腺疾病史OR=2．6180（95％CI：2．0275—3．3804）；吸烟OR=1．8576（95％CI：1．5394—2．2415）；饮酒OR=0．8137（95％CI：0．6196～1．0686）；饮茶OR=0．8625（95％CI：0．7646～0．9728）。结论]初潮年龄、口服避孕药、良性乳腺疾病史及吸烟是乳腺癌发生的危险因素，哺乳及饮茶则是乳腺癌的保护因素。

Meta-analysis of the Risk Factors in Chinese Female with Breast Cancer

Purpose] To explore the pathogenesis of breast cancer through appraising the main risk factors related to the incidence of breast cancer among Chinese female. Method] The results from 12 case-control studies on risk factors of breast cancer from 1996 to 2006 were analyzed by metaanalysis. Results] The pooled odds ratio values were： age at menarche （y）, OR=1.5401（95%CI： 1.3437-1.7654）; breast-feeding, OR=0.6837（95%CI：0.4779-0.9782）; oral-contraceptive use, OR= 1.3278 （95%CI：1.0627-1.6589）; history of benign breast disease, OR=2.6180 （95%CI：2.0275- 3.3804）; smoking, OR=1.8576（95%CI：1.5394-2.2415）; alcohol drinking, OR=0.8137（95%CI： 0.6196 - 1,0686）; tea drinking, OR =0.8625 （95 % CI ： 0,7646 -0.9728）. Conclusion] The risk factors influencing the incidence of breast cancer among Chinese female were age at menarche （y）, oralcontraceptive use, history of benign breast disease and smoking. The protective factors were breastfeeding and tea drinking.