Role ofBcl-2, Bax, andBak in spontaneous apoptosis and proliferation in neuroendocrine lung tumors: Immunohistochemical study |
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| Authors: | M. A. Pal’tsev S. A. Demura E. A. Kogan G. Jaques B. Zende |
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| Affiliation: | (1) Department of Pathological Anatomy, I. M. Sechenov Moscow Medical Academy, Moscow, Russia;(2) Department of Oncology, Hematology and Immunology, Phillips University, Marburg, Germany;(3) Institute of Pathology and Experimental Cancerogenesis, Seimmelweis University, Budapest, Hungary |
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| Abstract: | Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically and their apoptosis level was determined. Malignant carcinomas were characterized by increased apoptotic index and enhanced expression ofBcl-2, Bak, p53, andKi-67 compared to typical carcinoid. However, apoptosis in these tumors was not completed. Proteins of theBcl family play an important role in the regulation of spontaneous apoptosis in neuroendocrine lung tumors.Bcl-2 accumulating in the nucleus is a morphological analogue of phosphorylated inactive form of this protein, which does not inhibit apoptosis. Expression ofBcl-2 andBax decreases in small-cell lung carcinoma (SCLC) with metastases indicating attenuation of apoptosis and development of metastatic clones resistant to apoptosis induces. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 98–101, July, 2000 |
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| Keywords: | small-cell lung carcinoma typical carcinoid malignant carcinoid apoptosis biomolecular markers |
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