替罗非班在急诊冠脉介入治疗中的应用

目的:分析替罗非班与阿司匹林、氯吡格雷、低分子肝素合用于冠脉支架术时的疗效、安全性。方法:入选2008年3月~2009年6月64例确诊急性心肌梗死并行PCI治疗的病人,随机分为两组,每组32人,对照组常规治疗,治疗组在此基础上加用替罗非班。对两组病人在疗效、不良反应等方面进行比较。结果:两组病人在出血等不良反应方面没有太大差异,在疗效方面,治疗组在给药后7 d内全因死亡、顽固性心绞痛、再发心肌梗死方面均明显少于对照组,二者差异有统计学意义。结论:对于急性心肌梗死病人行支架植入术时,在常规治疗的基础上,加用替罗非班可以明显提高疗效,而不增加不良反应。

Tirofiban used in emergency treatment of coronary intervention

Objective: To analyze the efficacy,safety of tirofiban when used together with aspirin,clopidogrel,low molecular weight heparin for coronary stenting.Methods:64 cases confirmed acute myocardial infarction having recieved PCI during March 2008~June 2009 were randomly divided into two groups of 32 people.The control group was given conventional treatment and the treatment group was added with tirofiban.The two groups of patients were compared in efficacy,adverse reactions, etc.Results:There is no much difference in bleeding and other adverse reactions between the two groups.The cases in the treatment group of all-cause death within 7 days, refractory angina,myocardial infarction was significantly less than in the control group.The differences were statistically significant.Conclusion: During stent plantation operation for the patients with acute myocardial infarction,based on conventional treatment,adding tirofiban can significantly improve the efficacy without increasing adverse effects.