老年人良性阵发性位置性眩晕与血清同型半胱氨酸水平的关系

目的探讨血清同型半胱氨酸（Hcy）水平和老年人良性阵发性位置性眩晕（BPPV）发病的关系。方法收集年龄≥60岁的BPPV患者113例和年龄≥60岁的体检者84例，分别测定并分析Hcy、血生化检查及血压，以及高血压、糖尿病、冠心病、高脂血症、吸烟、饮酒等心脑血管疾病相关的危险因素。结果BPPV组和对照组Hcy水平比较差异有统计学意义（P＜0.05），而两组间的年龄、性别、TC、TG、HDL、LDL、空腹血糖、收缩压、舒张压、白蛋白、肌酐及高血压、糖尿病、冠心病、高脂血症、脑梗死、脑出血、吸烟及饮酒史等心脑血管疾病危险因素方面比较差异均无统计学意义（均P＞0.05）。进一步logistic多因素回归分析发现，高Hcy血症、相对较低年龄是老年BPPV患者发病的危险因素。结论高Hcy血症是老年BPPV患者发病的独立危险因素。

Relationship between serum homocysteine level and benign paroxysmal positional vertigo in elderly patients

Objective To investigate the relationship between serum homocysteine (Hcy) level and benign paroxysmal positional vertigo (BPPV) in elderly patients. Methods One hundred and thirteen patients with over 60 years admitted in the Jiaxing First Hospital from January 2014 to September 2015 (BPPV), and 84 healthy subjects over 60 years (control group) were enrolled in the study. The serum homocysteine and other blood biochemical parameters were measured, blood pressure was examined. The information of hypertension, diabetes, coronary heart disease, hyperlipidemia, smoking, alcohol consumption and other risk factors of cardiac and cerebral vascular disease were collected in two groups. Results There were significant differences in serum homocysteine in two groups; however, there were no significant differences in age, gender, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, fasting blood glucose, systolic blood pressure, diastolic blood pressure, albumin level, creatinine; and also there were no significant differences in risk factors of cardiac and cerebral vascular disease, include hypertension, diabetes, coronary heart disease, hyperlipemia, cerebral infarction, cerebral hemorrhage, smoking and drinking history. Logistic regression analysis showed that high homocysteine and younger age were the risk factors of BPPV in elderly patients. Conclusion Homocysteine is an independent risk factor for BPPV in elderly patients.