颅脑外伤后早期低氧应激肽、皮质醇和血管内皮细胞生长因子的表达及意义分析

目的：分析颅脑外伤后早期低氧应激肽、皮质醇和血管内皮细胞生长因子的表达及意义。方法：以我院收治的52例颅脑外伤患者为观察组,另选择50例健康者为对照组。于损伤早期分别对2组患者的血清HSP、皮质醇及脑组织VEGF进行检测。对比分析2组对象三项指标的表达水平及其与观察组患者病情严重程度及预后的关系。结果：观察组患者血清HSP、皮质醇表达水平及脑组织VEGF阳性率均高于对照组(P均＜0.05)。随着患者观察组患者病情的加重,患者血清HSP、皮质醇表达水平和脑组织VEGF阳性表达率逐渐升高(P＜0.05);同时,患者预后越差,患者血清HSP、皮质醇表达水平和脑组织VEGF阳性表达率越高(P＜0.05)。结论：颅脑外伤后早期患者低氧应激肽、皮质醇和血管内皮细胞生长因子呈高水平表达,且其与患者的病情程度及预后密切相关,可作为患者病情及预后评估的可靠指标。

[7]Seidberg NA,Clark RS,Zhang X,et al.Alterations in inducible72-kDa heat shock protein and the chaperone cofactor BAG-1in human brain after head in jury[J].J Neurochem.2003,84(3):514-521.

objective: Analysis of early stage after traumatic brain hypoxia stress peptide and cortisol and expression of vascular endothelial growth factor and its significance. Methods: 52 cases of traumatic patients in our hospital for observation group, another choice of 50 healthy volunteers as a control group. 2 groups respectively in early patients with HSP, cortisol in serum and brain tissue VEGF for testing. Comparison 2 group objects and expression level and three observation group, the severity and prognosis of patients with.Results: Observation group, HSP, cortisol in serum of patients with brain tissue VEGF expression and positive rates were higher than those in the control group (p <0.05). With the patient"s observational group condition aggravated, HSP expression and cortisol in serum of patients with brain tissue VEGF expression level and increased gradually (P<0.05) and the worse the prognosis, HSP expression levels, cortisol in serum of patients with brain tissue VEGF expression and higher (P<0.05). Conclusion:Early period after craniocerebral trauma patients with hypoxia stress peptide and cortisol and showed high levels of vascular endothelial growth factor expression and the degree of patient"s condition and prognosis, as reliable indicators of patient"s condition and prognosis.