| 肿瘤细胞多药耐药性与中药的逆转作用 |
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| 引用本文： | 丰俊东徐晓玉. 肿瘤细胞多药耐药性与中药的逆转作用[J]. 中国中药杂志, 2004, 29(9): 828-830 |
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| 作者姓名： | 丰俊东徐晓玉 |
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| 作者单位： | 重庆医科大学,中医药学院,重庆,400050 |
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| 摘 要： | 肿瘤细胞多药耐药 (MDR)是化疗失败的主要原因 ,近年来逆转肿瘤多药耐药的研究越来越受到重视。MDR的机制涉及P-gp ,MRP1,细胞凋亡 ,DNA修复异常 ,器官微环境等 ,作者总结了MDR机制研究的新进展 ,同时总结了中药逆转MDR的研究进展 ,并讨论它们的主要特点和作用机理。
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| 关 键 词： | 肿瘤 多药耐药 机制研究 中药 |
| 文章编号： | 1001-5302(2004)09-0828-03 |
| 收稿时间： | 2003-12-18 |
Tumor multidrug-resistance and reversing actions of traditional Chinese medicine |
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| FENG Jun-dong;XU Xiao-yu. Tumor multidrug-resistance and reversing actions of traditional Chinese medicine[J]. China Journal of Chinese Materia Medica, 2004, 29(9): 828-830 |
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| Authors: | FENG Jun-dong XU Xiao-yu |
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| Affiliation: | College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400050, China. fengjun-dong2001@sohu.com |
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| Abstract: | Tumor multidrug-resistance(MDR) is a majo r factor in chemotherapeutic failure. In recent years, the development of anti-MD R has become an important focus in research. The mechanisms of MDR relate to P- glycoprotein, MRP1, apoptosis, the unusual DNA repair, the organic micro-enviro ment, and so on. This review summarized the advances in MDR mechanism research. At the s ame time, it summarized the recent research of traditional Chinese medicine in reversing MDR. Furthermore, their mechanisms and major features of actions we re also discussed. |
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| Keywords: | tumor multidrug-resistance(MDR) traditio nal Chinese medicine |
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