野蔷薇果汁对乌拉坦诱发小鼠肺腺瘤的影响

本研究观察了野蔷薇果汁对乌拉坦诱发小鼠肺腺瘤的影响,并观察了实验第1、2、3、4、5月时小鼠免疫功能及脂质过氧化水平的改变。结果发现,野蔷薇果汁有明显的拮抗乌拉坦诱发小鼠肺腺瘤的作用,对乌拉坦引起的机体免疫状态的降低有拮抗作用,对小鼠自由基及其清除系统也有降低作用。

ANTAGONISTIC EFFECT OF ROSA DAVURICA PALL JUICE ON CANCER

The influence of Rosa davurica pall juice on pulmonary adenoma induced by urethan was observed in the experiment, which lasted for 20 weeks. 250 mice were divided into 4 groups at random. Group A was set as control receiving basal diet and tap water only. Another 3 groups were given basal diet, however, group B was given Rosa davurica pall juice 0.2ml/20g boody weight once a week, group C 0.1% urethan solution for drinking freely and group D 0.1% urethan solution plus the juice. The mouss body weight was weighed once a week; the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), the level of lipoperoxides (LPO), lymphocyte transformation and hemolysin were determined once a month, the pulmonary pathological examination was made also once a month. The obtained data were carried out with a 2×2 factorial analysis. The result were as follows:(1)the incidence of pulmonary adenoma of group C(100%) was significantly higher than that of group D (69%) at the e-nd of experiment (P<0.05).(2)Rosa davurica pall juice took a significant antagonistic effect to urethan on the levels of lymphocyte transformation and hemolysin (P<0.05).(3)though Rosa davurica pall juice showed an antagonistic tendency to urethan on the activities of SOD, GSH-Px and the level of LPO, it didn't show statistic significance.The result demonstrated that Rosa davurica pall juice could inhibit the pulmonary adenoma induce by urethan, as to what component played the role in antitumorigenesis and its antitumor function in human body still need further research.