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| 反复IVF-ET失败与卵细胞染色体的非整倍体异常 | |
| 引用本文： | 陈雯,朱桂金,Mettler,L. 反复IVF-ET失败与卵细胞染色体的非整倍体异常[J]. 中国妇幼保健, 2004, 0(18) |
| 作者姓名： | 陈雯 朱桂金 Mettler L |
| 作者单位： | 华中科技大学同济医学院附属同济医院妇产科，华中科技大学同济医学院附属同济医院妇产科，430030，Department，of，Gynecology，and，Obstetrics，University，Kiel，Germany 430030Department，of，Gynecology，and，Obstetrics，University，Kiel，Germany |
| 摘 要： | 目的:研究反复试管婴儿(IVF-ET)失败与卵细胞染色体非整倍体间的相关关系。方法:取反复IVF-ET失败和初次行IVF-ET患者助孕技术后未能受精成功的卵母细胞,采用多色荧光原位杂交方法检测两组卵母细胞13、16、18、21和22号染色体的核型情况。结果:反复IVF-ET失败组卵母细胞的非整倍体率为66.67%,明显高于初次行IVF-ET患者的未受精卵母细胞的非整倍体率为30.77%(P<0.025)。结论:卵细胞的非整倍体异常可能是导致反复lVF-ET失败的一个重要原因。 |
| 关 键 词： | 反复IVF-ET失败 人卵细胞 非整倍体 |
Correlation between repeated IVF-ET failure and oocyte aneuploidy |
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| CHEN Wen,ZHU Gui-Jin,Mettler L. Correlation between repeated IVF-ET failure and oocyte aneuploidy[J]. Maternal and Child Health Care of China, 2004, 0(18) | |
| Authors: | CHEN Wen ZHU Gui-Jin Mettler L |
| Affiliation: | CHEN Wen,ZHU Gui-Jin,Mettler L. Department of Obstetrics and Gynecology,Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China |
| Abstract: | To investigate the correlation between repeated IVF-ET failure (RIF) and oocyte aneuploidy. Methods: Multicolor fluorescence in situ hybridization (M-FISH) was applied to check the chromosome status in oocytes for chromome 13, 16, 18, 21 and 22- Results: 66. 7% of oocytes from RIF patients were aneuploidy, much higher than the aneuploidy rate from the patients with first IVF-ET(P<0. 025). Conclusion: Oocyte aneuploidy could be an important reason of repeated IVF failure. |
| Keywords: | Repeated IVF-ET failure Oocyte Aneuploidy |
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