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| 老年急性冠脉综合征患者应用替罗非班治疗出血危险因素分析 | |
| 引用本文： | 武强,王曙霞,郭豫涛,张璐,蔡军. 老年急性冠脉综合征患者应用替罗非班治疗出血危险因素分析[J]. 心脏杂志, 2011, 23(2): 218-220 |
| 作者姓名： | 武强 王曙霞 郭豫涛 张璐 蔡军 |
| 作者单位： | 解放军总医院:1.国际医学中心,2.老年心内科,北京 100853 |
| 基金项目： | 中央保健专项资金科研资助项目课题(205) |
| 摘 要： | 目的: 分析老年急性冠脉综合征(ACS)患者应用替罗非班抗血小板治疗出血的危险因素。方法: 67例年龄大于60岁的老年ACS患者接受替罗非班持续静脉滴注36～48 h，观察用药开始至停药3 d内患者出血情况，并对出血可疑危险因素进行单因素和多因素Logistic回归分析。结果: 发生出血6例（9%）,其中重度出血1例，轻度出血5例。多因素Logistic回归分析表明吸烟，OR=3.2, 95%CI 2.2-4.6；年龄每增加10岁，OR=1.4，95%CI 1.1-1.7；血小板聚集率每减少10%，OR=1.6，95%CI 1.2-1.9；肌酐清除率每减少10 ml/min,OR=1.2，95%CI 1.0-1.4；抗凝药及抗血小板药每增加一个，OR=4.2, 95%CI 2.0-5.2。结论: 抗血小板与抗凝药联合应用，吸烟、高龄、血小板聚集率降低、肌酐清除率降低为老年ACS患者应用替罗非班抗血小板治疗出血的主要危险因素。 |
| 关 键 词： | 替罗非班 出血 急性冠脉综合征 危险因素 |
| 收稿时间： | 2010-03-24 |
Risk factors of bleeding complication of tirofiban in elderly patients with acute coronary syndrome |
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| WU Qiang,WANG Shu-xia,GUO Yu-tao,ZHANG Lu,CAI Jun. Risk factors of bleeding complication of tirofiban in elderly patients with acute coronary syndrome[J]. Chinese Heart Journal, 2011, 23(2): 218-220 | |
| Authors: | WU Qiang WANG Shu-xia GUO Yu-tao ZHANG Lu CAI Jun |
| Affiliation: | WU Qiang1,WANG Shu-xia2,GUO Yu-tao2,ZHANG Lu2,CAI Jun1(1.International Medical Center,2.Department of Geriatric Cardiology,PLA General Hospital,Beijing 100853,China) |
| Abstract: | AIM: To evaluate the risk factors of bleeding complication of tirofiban in elderly patients with acute coronary syndrome(ACS).METHODS: A total of 67 patients(>60 years) with ACS were enrolled from August 2008 to February 2009 and were all given aspirin,clopidogrel,low molecular weight heparin,tirofiban and other anti-ischemic therapy.Tirofiban was given continuously for 36-48 h.Possible risk factors of bleeding complication analyzed included age,sex,smoking,hypertension,diabetes mellitus,blood platelet numb... |
| Keywords: | tirofiban acute coronary syndrome safety risk factors |
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