脱细胞异种(猪)真皮基质作为填充材料的初步研究与应用

目的：为临床修复体表凹陷畸形寻求良好的填充材料。方法：用自制脱细胞异种（猪）真皮基质，植入兔皮下，定时进行测量，并进行光镜及电镜观察。临床应用2例。结果：脱细胞异种（猪）真皮基质植入后观察1年，仅在4周内有极轻微的炎性反应，无排斥反应，2周左右有成纤维细胞及毛细胞血管长入，吸收率低于对照组。2例临床应用填充效果较满意，质地较软，无破溃、外露。结论：脱细胞异种（猪）真皮基质组织相容性好，吸收率低，质地软，是一种有良好前景的软组织填充材料。

Studies on xenogenic acellular dermal matrix as a filling material

Objective To explore the biological reaction of swine acellular dermal matrix as a filling material for body surface deformity. Methods Xenogenic acellular dermal matrix was implanted into the hypoderm of rabbits. The implants were measured and observed with pathological and transmission electron microscopic technique at regular times. The results were compared with implantation of autologous dermis and swine dermis. Results The implanted xenogenic acellular dermal matrix and autologous dermis had slight inflammatory reaction. At 2 weeks there were fibroblasts and capillaries in the implants. The absorptivity of the xenogenic acellular dermal matrix was lower than the swine dermis. The xenogenic acellular dermal matrix was used in 2 clinical cases and obtained good result. Conclusion The xenogenic acellular dermal matrix is an ideal material with good compatibility feature and low absorptivity.;