2型糖尿病大血管病变与C肽水平相关性研究

目的探讨2型糖尿病（T2DM）性大血管病变与C肽之间的关系。方法对252例T2DM患者进行临床资料的回顾性分析,根据有无血管病变分为大血管病变组及对照组,分析两组患者病史及空腹血糖（FBG）、餐后2h血糖（PBG）、糖化血红蛋白（HbA1C）、空腹C肽（FCP）、餐后2h C肽（PC）、甘油三脂（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、尿酸（UA）等临床指标。结果两组间比较,大血管病变组患者的年龄较大、病程较长、FCP较低,差异有显著统计学意义（P〈0.01）；FBG、PBG、HbA1C及LDL-C均高于对照组,HDL-C低于对照组,差异有统计学意义（P〈0.05）,然而PC差异无统计学意义（P＆gt；0.05）。Logistic回归分析结果显示年龄、吸烟、FBG为2型糖尿病大血管病变危险因素,（P〈0.05）,而HDL-C及FC为保护因素（P〈0.05）。结论 2型糖尿病的大血管病变是常见并发症,C肽可能对2型糖尿病的大血管病变具有保护作用。

Study on the correlation between macrovascular disease in type 2 diabetes and C peptide level

Objective To study the correlation between macrovascular disease and C peptide level in patients with type 2 diabetes.Methods The clinical data of 252 patients with type 2 diabetes（T2DM） was retrospectively analyzed.These patients were divided into macrovascular disease group and control group,it was grouped according to the presence or absence of vascular lesions.The basic information,history,biochemical criterion including fasting glucose（FBG）,postprandial glucose（PG）,glycated hemoglobin（HbA1C）,fasting C-peptide（FCP）,postprandial C-peptide（PC）,triglyceride（TG）,cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,serum uric acid（UA） were analyzed.Results The results shows that Compared with the control group,the macroangiopathy group has the older age,the longer course and the lower FCP（P 0.01）,the FBG,PBG,HbA1C and LDL-C are higher than the control group（P 0.05）,but the HDL-C is lower（P 0.05）,the PC differences are not statistically significant（P 0.05）.The age,cigarette smoking,FBG are the independent risk factors in the macrovascular disease in patients with T2DM,while the HDL-C and FCare theprotect factors,which is showed by the logistic regression.Conclusion V ascular lesions were common complications in T2DM patients,C peptide may have a protective effect on the macrovascular disease in patients with T2DM.