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| 姜黄素对肿瘤细胞增殖的影响 | |
| 引用本文： | 张君,童钟,李迎霞,孙忠杰,李鸿君. 姜黄素对肿瘤细胞增殖的影响[J]. 安徽医药, 2014, 0(8): 1545-1548 |
| 作者姓名： | 张君 童钟 李迎霞 孙忠杰 李鸿君 |
| 作者单位： | 安徽医科大学第三附属医院·合肥市滨湖医院普外科，安徽合肥 230022;北京协和药厂,北京,102600 |
| 摘 要： | 目的观察姜黄素在体外对多种常见肿瘤细胞增殖的影响。方法分别用0、1、2、5、10、20、50、100μmol·L^-1姜黄素处理人乳腺癌细胞（MCF-7）、人子宫颈癌细胞（Hela）、人肺癌细胞（A549）、人肝癌细胞（HepG-2）24、48、72 h,采用MTT法检测细胞增殖抑制率,并计算72 h时的半数抑制浓度（50%concentration of inhibition,IC50）。结果姜黄素在体外对上述4种细胞增殖均有抑制作用,且呈浓度、时间依赖性。结论姜黄素具有抑制多种肿瘤细胞增殖的作用。 |
| 关 键 词： | 姜黄素 肿瘤细胞 细胞增殖 |
Effect of curcumin on tumor cell proliferation |
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| Affiliation: | ZHANG Jun , TONG Zhong , LI Ying-xia, et al ( 1. Department of The Liver, Gall and Blood Vessels Surgery, Binhu Hospital of Hefei, Hefei 230022, China ; 2. Beijing Union Pharmaceutical Factory ,Beijing 102600, China) |
| Abstract: | Objective To observe the effects of Curcumin on 4 kinds of common tumor cells. Methods MTT method was used to observe the inhibitory effects of 0,1,2,5,10,20,50 and 100 μmol·L^-1Curcumin on 4 kinds of tumor cells（MCF-7,Hela,A549 and HepG-2） for 24,48 and 72 h. IC50at 72 h in different kinds of cells was calculated. Results Curcumin exerted inhibitory effects on the proliferation of MCF-7,Hela,A549 and HepG-2 cells. The anti-proliferation effect of Curcumin had a dose-effect relationship and was in a time-dependent manner. Conclusion Curcumin can inhibit the proliferation of multiple tumor cells. |
| Keywords: | curcumin tumor cells cell proliferation |
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