HER-2与大肠癌患者预后的关系研究

目的研究人类表皮生长因子受体-2（HER-2）在大肠癌患者中的表达及特征,了解其与患者预后的相关性。方法采用免疫组化法检测121例大肠癌组织及66例正常大肠组织中HER-2的表达情况,比较大肠癌组织中不同的病理特征和临床资料与HER-2表达的相关性。结果正常组织中HER-2表达阳性12例（18.2%）,大肠癌组织中阳性46例（38.0%）,两组比较差异有统计学意义（P〈0.05）;HER-2的表达与年龄、性别、肿瘤直径和部位、远端转移无关（P〉0.05）,与分化程度、分期、淋巴结转移有明显的相关性（P〈0.05）。HER-2高表达的大肠癌患者5年生存率低于低表达患者（P〈0.05）。结论HER-2的表达与大肠癌的发生有关,可以作为早期检测及评价预后的标志。

Relationship between human epidermal growth factor-2 expression and prognosis of patients with colorectal cancer

Objective To investigate the expression of HER-2 in patients with colorectal cancer and the relationship between its expression and patients,prognosis. Methods Immunohistochemistry was used to detect the expression of HER-2 in 121 cases of colorectal cancer tissue and 66 cases of normal colorectal tissue. Pathological characteristics and clinical data were compared between those two groups. Results HER-2 was positively expressed in 12 cases（18. 2%） of normal tissue and 46 cases（38. 0%） of colorectal cancer tissue,and the difference was statistically significant（P〈0. 05）. The overexpression of HER-2 was not associated with patients,age,gender,tumor size,location and distant metastases（ P〉0. 05）,but associated with differentiation stage,Dukes,stage and lymphatic metastases（P〈0. 05）. The colorectal cancer patients with overexpression of HER-2 had a significantly lower five-year survival than those with low expression（P〈0. 05）. Conclusions The expression of HER-2 was associated with the occurrence of colorectal cancer,which could be used as a marker for early detection and prognosis.