| 蓖麻毒素诱导U937细胞分泌IL-6和IL-8的作用 |
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| 引用本文： | 董巨莹,张小光,赵英,药立波,苏成芝. 蓖麻毒素诱导U937细胞分泌IL-6和IL-8的作用[J]. 中国免疫学杂志, 2000, 16(8): 404-406 |
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| 作者姓名： | 董巨莹 张小光 赵英 药立波 苏成芝 |
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| 作者单位： | 1. 福建厦门大学生物系,厦门,361005
2. 第四军医大学生化与分子生物学教研室,西安,710032 |
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| 基金项目： | 国家自然科学基金!资助 (No .3950 0 1 2 2 ) |
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| 摘 要： | 目的：进一步研究蓖麻毒素是否具有诱生Ｕ９３７细胞分泌细胞因子作用。方法：采用ＭＴＴ法检测了蓖麻毒素对Ｕ９３７细胞的毒性,并采用ＥＬＩＳＡ法测定细胞２上清中的Ｉ－６和ＩＬ－８。结果：蓖麻毒素对Ｕ９３７细胞的生具有时间效应及剂量效应。随着作用时间的延长。诱生２种细胞因子的量逐渐增加;随蓖麻毒素剂量的增加,诱生２种细胞因子的量均减少。结论：蓖麻毒素诱导２种细胞因子的产生为其抗癌应用或其它作用提供理论依据
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| 关 键 词： | 蓖麻毒素 U937细胞 IL－6 IL－8 |
Induction of IL-6 and IL-8 on U937 cell by ricin |
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| DONG Ju-Ying,ZHANG Xiao Guang,ZHAO Ying et al. Induction of IL-6 and IL-8 on U937 cell by ricin[J]. Chinese Journal of Immunology, 2000, 16(8): 404-406 |
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| Authors: | DONG Ju-Ying ZHANG Xiao Guang ZHAO Ying et al |
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| Affiliation: | DONG Ju-Ying,ZHANG Xiao Guang,ZHAO Ying et al.Department of Biochemistry and Molecular Biology,the Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | Objective:Ricin is a glycoprotein from ricinus communis seeds.In order to study induction of cytokine by ricin.Methods:The toxicity has been detected by MTT method and production of IL 6 and IL 8 has been detected by Kit.Results:It showed that the toxicity of ricin for U937 cell has time responses and dose responses. Both of cytokines have increased as the time is prolonged.Conclusion: Production of cytokines may have a role in the pathogenesis of ricin toxic effect and anticancer. |
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| Keywords: | Ricin U937 cells Interleukin 6(IL 6) Interleukin 8(IL 8) |
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