膀胱移行细胞癌增殖细胞核抗原与肿瘤间质微血管密度的表达与临床及预后的意义

目的：探讨膀胱移行细胞癌组织中增殖细胞核抗原（ＰＣＮＡ）与肿瘤间质微血管密度（ＭＶＤ）的表达及其临床与预后的意义。方法：对７２例膀胱移行细胞癌进行ＰＣＮＡ及第Ⅷ因子相关抗原（ＶＷＦＬ：Ａｇ）单克隆抗体免疫组化染色。结果：ＰＣＮＡ增殖指数与肿瘤间质微血管密度之间存在正相关性，二者的表达皆与膀胱移行细胞癌的病理分级显著相关，１级与２级、２级与３级之间存在显著性差异（Ｐ〈０．０１），侵袭性肿瘤明显高于线

Clinical and Prognostic Significance of PCNA Expression and Tumor Interstitial Vascular Density in Transitional Cell Bladder Cancer

Objective: To evaluate the clinical and prognostic significance of proliferating cell nuclear antigen (PCNA) expression and tumor interstitial microvessel density (MVD) in transitional cell bladder cancer. Methods: The expression of PCNA and MVD in 72 cases of transitional cell bladder cancer were determined with anti-PCNA McAb and anti-VWF by Ag McAb immunohistochemical staining. Results: It was shown that the expression of PCNA in bladder cancer was positively correlated to tumor interstitial vascular density. These two indices increased with the escalation of the tumor grade ( P <0.01), and were higher in tumour with invasion than not ( P <0.01). The PCNA and MVD expression in resurrent tumours were higher than those without ( P <0.01). Conclusion: The results suggest that the expression of PCNA is a malignant phenotype in transitional cell bladder cancer and that it is related to the formation of tumor interstitial vascularity. The PCNA expression and MVD measurement is of significance in assessing the prognosis of transitional cell bladder cancer.