奥曲肽和生长抑素与垂体后叶素治疗食管底静脉曲张破裂大出血的疗效对比

目的：观察生长抑素及奥曲肽对食管胃底静脉内张破裂大出血（ＥＧＶＢ）的疗效，方法：９０例肝硬化ＥＧＶＢ病人随机分成３组：生长抑素组用施他宁（１４肽生长抑素）２５０ｕｇｉｖ后以２５０ｕｇ／ｈ的速度持续静脉滴注５天，奥曲肽组用善宁（八肽生长素）０．１ｍｇｉｖ后以２５ｕｇ／ｈ的速度持续静脉滴注５天，垂体后叶素组用垂体后叶素０．３ｕ／ｍｉｎ的速度持续静脉滴注５天，３组的年龄，性别、肝功能分级、出血量、输血量等方面均无统计学差异。结果：生长抑素组止血率为８０．０％（２４／３０）。结论：施他要及善宁治疗肝硬化ＥＧＶＢ的疗效均明显好于垂体后叶素，而善宁因其价格明显 于施他宁可作为首选治疗药物，施他宁则因止血速度快而可根据病人的经济条件选择作为前期使用的药物。

Therapeutic comparison of somatostatin and Octreotide in Treating EsophahealGastric Varicose Bleeding

Objective To observe the therapeutic efficacy of somatostatin and octreotide in treating esophageal and gastric varicose bleeding (EGVB). Methods 90 hepatic cirrhosis cases were divided at random into two coups: somatostatin group and octreotide group and pituitrin group. No difference was found among three groups in the age, sex, liver function, bleeding volume and intravenous in- fusion. Results The hemostasis rate in somatostatin coup was 80. 00% (24/30) with the death rate of 6. 67% (2/30); the hemostasis rate in octreotide group was 76. 67% (23/ 30) with the death rate of 13. 33% (4/ 30); the hemostasis rate in pituitrin group was 53. 33% (16/30) with the death rate of 36. 67% (11/30). Conclusion The therapeutic efficacy of somatostatin and octreotide was better than that of pituitrin in stopping EGVB.