| 细胞凋亡与细胞增殖在胆囊肿瘤形成中的作用 |
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| 引用本文： | 陈汝福,邹声泉,钱家勤,李英亮,郑国华. 细胞凋亡与细胞增殖在胆囊肿瘤形成中的作用[J]. 胃肠病学和肝病学杂志, 2000, 9(1): 31-33 |
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| 作者姓名： | 陈汝福 邹声泉 钱家勤 李英亮 郑国华 |
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| 作者单位： | 1. 同济医科大学附属同济医院普外科,武汉市,430030
2. 山东省东营市人民医院外科,257000 |
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| 摘 要： | 目的 探讨细胞凋亡和细胞增殖在胆囊肿瘤发生发展中的作用。 用原位末端标记法和免疫组织化学染色１、检测２４例胆囊癌和１６例胆囊腺瘤中的凋亡细胞数和ＰＣＮＡ及ｂｃｌ－２癌基因的表达情况。结果 胆囊腺癌中的凋亡细胞数明显低于胆囊癌；分化好的胆囊癌中的凋亡细胞数低于分化差的胆囊腺癌。ＰＣＮＡ和ｂｃｌ－２的阳性表达率在胆囊癌中明显高于胆囊腺瘤。结论胆囊癌不仅有较高的增殖能力，而且有很高的细胞凋亡率。细胞凋亡
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| 关 键 词： | 胆囊肿瘤 细胞凋亡 PCNA bcl－2 免疫组化技术 |
| 修稿时间： | 1997-12-15 |
Effect of apoptosis and proliferation in gallbladder neoplasms |
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| Chen Rufu,Zou shengquan,Qian jiaqin et al. Effect of apoptosis and proliferation in gallbladder neoplasms[J]. Chinese Journal of Gastroenterology and Hepatology, 2000, 9(1): 31-33 |
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| Authors: | Chen Rufu Zou shengquan Qian jiaqin et al |
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| Affiliation: | Chen Rufu,Zou shengquan,Qian jiaqin et al. Department of general surgery,Tongji hospital,Tongji medical uviversity,Wuhan 430030 |
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| Abstract: | Aim To investigate the effects of apoptosis and proliferation in gallbladder neoplasms.Methods The number of the apoptotic cells,the positive expression of PCNA and bcl-2 oncoprotein were observed in 24 gallbladder carcinomas and 16 gallbladder adenomas using in situ end labeling (ISEL) method and immunohistochemical staining.Result The numbers of apoptosis in gallbladder adenoma were significantly lower than that in gallbladder carcinoma(P<001);well differentiated gallbladder carcimoma has less apoptotic cells than pooly differentiated gallbladder carcinoma does (P<005).The expression rates of PCNA and bcl-2 in gallbladder cacinoma were significantly higher than that in gallbladder adenoma (P<005).Conclusion Gallbladder carcinoma cell not only has highly proliferative ability,but also has many apoptotic cells.Apoptosis may play an important role in the pathogenesis of gallbladder carcinoma. |
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| Keywords: | Gallbladder neoplasmas Apoptosis PCNA Bcl-2 ISEL Immunohistochemistry |
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