| 左旋氧氟沙星对氨茶碱药物动力学的影响 |
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| 引用本文： | 朱永泉,谢守霞,宁德俄,董淳. 左旋氧氟沙星对氨茶碱药物动力学的影响[J]. 中国临床药学杂志, 1996, 0(4) |
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| 作者姓名： | 朱永泉 谢守霞 宁德俄 董淳 |
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| 作者单位： | 深圳市人民医院药剂科临床药学室!深圳518020 |
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| 摘 要： | 采用荧光偏振免疫分析法(FPIA),在7名志愿者身上,对氨茶碱单用及与左旋氧氟沙星合用后,血中氨茶碱浓度的变化进行观测.结果表明,合用左旋氯氟沙星后氨茶碱消除速率常数k降低13.6%,清除率CL下降15.6%,半衰期T_1/2延长16.5%(P<0.05),但对峰浓度C_(max)、曲线线下面积AUC,表观分布容积V_d无显著影响(P
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| 关 键 词： | 左旋氧氟沙星 氨茶碱 药物动力学 |
THE EFFECT OF LEVOFLOXACIN ON PHARMACOKINETICS OF AMINOPHYLLINE IN HEALTHY VOLUNTEERS |
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| ZHU Yong-quan XIE Shou-xia NING De-e DONG chun. THE EFFECT OF LEVOFLOXACIN ON PHARMACOKINETICS OF AMINOPHYLLINE IN HEALTHY VOLUNTEERS[J]. Chinese Journal of Clinical Pharmacy, 1996, 0(4) |
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| Authors: | ZHU Yong-quan XIE Shou-xia NING De-e DONG chun |
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| Abstract: | Aminophylline in blood was determined by FPIA for 7 healthy volunteers having taken aminophylline or aminophylline combined with levofloxacin. The results indicated that levofloxacin made the elimination half life of aminophylline prolong,clearance and elimination rate constant reduced (P<0. 05). There was no significant statistical differences in the apparent distribution volume, the area under the curve and the peak concentration of aminophylline. |
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| Keywords: | levofloxacin aminophylline pharmacokinetics |
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