子宫内膜容受性与白血病抑制因子的相关性

子宫内膜容受性在胚胎植入中起关键作用,约2/3的胚胎植入失败是由于子宫内膜容受性不佳。白血病抑制因子（leukemia inhibitory factor,LIF）是子宫内膜容受性的重要生物学标志物之一,其在种植窗子宫内膜腺上皮高表达,参与调控胚胎植入过程中子宫上皮细胞的信号转导,将子宫内膜从非接受状态转化为接受状态。LIF表达异常可使子宫内膜容受性受损,与不孕症的发生密切相关,且其表达具有类固醇激素依赖性,并受多种细胞因子和生长因子调控。综述LIF在子宫内膜容受性的建立、胚胎植入、子宫内膜蜕膜化过程中的表达、相关信号转导通路及影响因素的研究进展,以期为子宫内膜容受性的诊治提供新的思路。

Leukemia Inhibitory Factor Related to Endometrial Receptivity

Endometrial receptivity plays a key role in embryo implantation, and 2/3 of embryo implantation failures are due to poor endometrial receptivity. Leukemia inhibitory factor (LIF) is an important biological marker of endometrial receptivity. The expression of LIF is highly upregulated in the endometrial glandular epithelium during the implantation window. LIF participates in the regulation of signal transduction of endometrial epithelial cells during embryo implantation, which may transform the endometrium from a non-receptive state to a receptive state. Abnormal expression of LIF impaires endometrial receptivity, which is closely related to the occurrence of infertility. Studies have showed that the expression of LIF is steroid-dependent, and that the expression can also be regulated by a variety of cytokines and growth factors. This paper describes the expression of LIF, signal transduction pathway and influencing factors of LIF expression in the establishment of endometrial receptivity, embryo implantation and decidualization, providing new ideas for the diagnosis and treatment of endometrial receptivity.