结核病DNA疫苗及其作用机制研究进展

为实现到2050年在全球范围内根除结核病(Tuberculosis,TB)这一宏伟目标,迫切需要开发新的TB疫苗和疫苗接种策略.虽然卡介苗(Bacille Calmette-Guérin,BCG)在保护儿童免受粟粒性结核和结核性脑膜炎等方面获得了成功,但其对成人肺结核(Pulmonary tuberculosis,PT...

Research progress in tuberculosis DNA vaccine and its action mechanism

In order to achieve the grand goal of eliminating tuberculosis (TB) globally by 2050, it is urgently needed to develop novel TB vaccines and vaccination strategies. Although Bacille Calmette-Guérin (BCG) has been succeeded in protecting children from miliary tuberculosis and tuberculous meningitis, its protective effect on adult pulmonary tuberculosis (PTB) is still weak (0-80%). To date, a dozens of novel TB vaccines, including first-generation and second-generation vaccines, are in different stages of preclinical or clinical research. As the third-generation vaccine, nucleic acid vaccines have gradually entered people's field of vision with the development of medical technology. This review mainly summarizes the immunological mechanism of TB DNA vaccine, the current status of TB DNA vaccine research, the strategy of TB DNA vaccine immunity enhancement, and the problems and application prospects of TB DNA vaccine. We hope to provide new ideas and perspectives for the development of safer and more efficient novel TB DNA vaccines.