前列腺特异性膜抗原核素显像及治疗在分化型甲状腺癌中的应用进展

分化型甲状腺癌（DTC）已成为最常见的头颈部肿瘤，大多数DTC患者经治疗后预后良好，但仍有部分转移性及失分化患者缺乏有效的诊断及治疗手段。放射性核素标记的前列腺特异性膜抗原（PSMA）药物已被应用于前列腺癌患者的显像和治疗中，而其在DTC中应用的研究目前仍处于探索阶段。笔者对DTC靶向PSMA显像及治疗的应用现状及前景进行综述，并提出未来的研究方向。

Application progress of PSMA in the imaging and treatment of differentiated thyroid cancer

Differentiated thyroid cancer(DTC) has become the most common head and neck tumor, and most DTC patients have a good prognosis after treatment. However, patients with metastasis and loss of differentiation have a poor prognosis and lack of effective diagnosis and treatment. Radiopharmaceuticals targeting prostate specific membrane antigen (PSMA) have been used in imaging and treatment of patients with prostate cancer, but the research on DTC is still at the exploratory stage. In this paper, the application status and prospect of targeted PSMA imaging and treatment of DTC were reviewed, and the future perspectives were also presented.