肺腺癌患者EGFR基因突变情况及影响因素分析

目的 探讨肺腺癌患者表皮生长因子受体（EGFR）基因突变情况及与临床、影像学及病理学特征的相关性。方法 选择2017年8月至2021年7月在海南省某肿瘤医院诊治的370例肺腺癌患者作为研究对象，根据EGFR基因检测结果分为野生型组和突变型组，将2组患者的性别、年龄、分期、腺癌类型、IASLC分级、组织学亚型、CT影像学特征等对EGFR突变的影响进行单、多因素分析。结果 经EGFR基因检测，共有EGFR基因突变患者172例，EGFR野生型患者198例，基因突变率为46.49%；其中EGFR基因19号外显子突变75例，占突变组43.60%;EGFR基因21号外显子突变97例，占突变组59.40%。经多因素Logistic回归分析，女性、有吸烟史、有毛刺征、有空气支气管征、乳头型浸润型黏液性腺癌是EGFR突变的危险因素（均P<0.05），微浸润腺癌是EGFR突变的保护因素（P<0.05）。EGFR基因19号外显子、21号外显子突变患者的临床资料、影像学及病理学特征均无明显差异（均P>0.05）。结论 肺腺癌患者EGFR基因突变具有相关的影像学、病理学特征，对制定患者的个性化...

EGFR gene mutation and its influencing factors in patients with lung adenocarcinoma

Objective To investigate the mutation of EGFR gene in patients with lung adenocarcinoma and its correlation with clinical, imaging, and pathological features. Methods A total of 370 patients with lung adenocarcinoma who were diagnosed and treated in a cancer hospital in Hainan Province from August 2017 to July 2021 were selected as the research subjects. According to the results of EGFR gene detection, they were divided into wild-type group and mutation group. The data of sex, age, stage, type of adenocarcinoma, IASLC grade, histological subtype, and CT inmaging characteristics of the two groups were analyzed by univariate and multivariate regression analysis. Results After EGFR gene detection, there were 172 patients with EGRF gene mutation and 198 patients with EGFR wild type, the gene mutation rate was 46.49%; 75 patients had EGFR gene exon 19 mutation, accounting for 43.60% of the mutation group; 97 patients had EGFR gene exon 21 mutation, accounting for 59.40% of the mutation group. Multivariate Logistic regression analysis showed that female, smoking history, burr sign, air bronchus sign, and papillary invasive mucinous adenocarcinoma were risk factors for EGFR mutation （all P<0.05）; Minimally invasive adenocarcinoma was a protective factor for EGFR mutation （P<0.05）. There was no significant difference in clinical data, imaging, and pathological features between patients with EGFR gene exon 19 and exon 21 mutations （all P>0.05）. Conclusion EGFR gene mutation in patients with lung adenocarcinoma has related imaging and pathological features, which has reference value for formulating personalized treatment plan for patients.