上皮-间质转化和蜕膜化与子宫内膜容受性

人类生殖过程涉及各种复杂因素,其中胚胎能否着床是受孕过程中的关键步骤。顺利的着床需要有正常生命力的胚胎在适当的时间植入具有接受性的子宫内膜,且胚胎与内膜达到同步交流状态。着床过程中任何一个环节出现差错都会影响妊娠率,而子宫内膜容受性下降可能是导致不孕的主要原因之一。着床初期子宫内膜上皮细胞发生上皮-间质转化（epithelial-mesenchymal transition,EMT）为后续胚胎的植入做准备,随后子宫内膜间质细胞发生蜕膜化为胚胎提供良好的发育环境。这提示EMT与蜕膜化是维持子宫内膜容受状态的基本条件,而良好的子宫内膜容受性是胚胎植入并充分发育的生物学基础。

Epithelial-Mesenchymal Transition and Decidualization in Endometrial Receptivity

Implantation of the embryo is a key step in the process of conception which involves complex factors. Successful implantation entails a viable embryo to be implanted into an acceptable endometrium at an appropriate time, and a state of synchronous communication between the embryo and the endometrium. Errors in any part of the implantation process will affect the pregnancy rate, wherein decreased endometrial receptivity may be implicated as one of the major causes of infertility. During the early stage of implantation, endometrial epithelial cells undergo epithelial-mesenchymal transition to facilitate embryo adhesion, followed by decidualization of endometrial stromal cells to provide a suitable environment for embryo development. This suggests that epithelial-mesenchymal transition and decidualization is the fundamental condition for maintaining the receptive state of the endometrium, and an acceptable endometrium is the biological basis for embryo implantation and full development.