老年妇女乳腺癌48例临床病理特点分析

目的]探讨老年乳腺癌病理特点.[方法]回顾分析 48例 65岁以上老年女性乳腺癌患者雌激素受体 （ER）、孕激素受体 （PR）、人表皮生长因子受体2 （C-erbB-2）、P53、肿瘤大小、淋巴结转移等预后因子, 以同期 69例65岁以下非老年女性乳腺癌患者作为对照组.[结果]65岁以上老年组乳腺癌 ER（＋）、PR（＋）较非老年组乳腺癌有较高的表达,差异有显著性（P〈0.05）;老年乳腺癌P53、C-erbB-2阳性表达率低于非老年组,差异有显著性（P〈0.01）.老年组乳腺癌淋巴结转移率低于非老年组（P〈0.05）.[结论]65岁以上老年女性乳腺癌患者往往分化程度更高、侵袭性更低、预后更好.

Analysis of Clinicopathologic Characteristics in Breast Cancer of 48 Senile Women

[Objective]To explore the pathological features of breast cancer in senile women. [Methods] Forty eight cases of breast cancer in women aged over 65 years old were analyzed retrospectively. Sixty nine cases of breast cancer in women aged below 65 years old were selected as the control group. Estrogen receptor （ER）, progesterone receptor （PR）, human epidermal growth factor receptor （C-erbB-2）, P53, tumor size, lymph node metastasis and other prognostic factors were observed. [Results] The expression of ER （＋） and PR （＋） in senile group was higher than that in control group, and the difference was significant （ P〈0.05）. The positive rate of c-erbB-2 and P53 in senile group was lower than that of control group （ P〈0.05）. And the incidence of lymph node metastasis in senile group was lower than in control group（ P 〈0.05）. [Conclusion]Breast cancer in senile women aged over 65 years old has high differentiation, low invasion, and its prog- nosis is better.