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肝细胞再生刺激素治疗重型肝炎318例疗效分析的对照研究
引用本文:许家璋,鞠九龙,邬详惠,张新年,闵贤,胡德昌,陈浩坤,刘家琴,杨冬明,印永宏,李育贤.肝细胞再生刺激素治疗重型肝炎318例疗效分析的对照研究[J].中华实验和临床病毒学杂志,1995(1).
作者姓名:许家璋  鞠九龙  邬详惠  张新年  闵贤  胡德昌  陈浩坤  刘家琴  杨冬明  印永宏  李育贤
作者单位:南京解放军第81医院,上海医科大学华山医院,南京市钟阜医院,南京医科大学第一附属医院,上海医科大学中山医院,无锡市传染病院,安徽医科大学附院,扬州医学院附院,解放军第86医院,解放军第100医院
摘    要:采用解放军第81医院和南京大学制药厂共同研制的国家一类新药──肝细胞再生刺激素(Hepaticregenerativestimulus,HRS),简称肝再生素治疗重型肝炎318例总有效率(即存活率)达69.2%(220/318)明显优于对照组30.3%(33/109)(P<0.001)。进一步分析表明:无论是双盲随机对照,非盲随机对照和非对照的开放性研究,各组用HRS治疗重型病毒性肝炎的存活率均在70%左右,而对照组仅为30%左右,提示:HRS治疗重型病毒性肝炎有明显的疗效。

关 键 词:肝炎/治疗,△肝细胞再生刺激素

A Double-blind Study of Hepatic Regenerative Stimulus (HRS) on Advanced Viral Hepatitis:Analysis of 318 Cases
Xu Jazhag,Ju Jiulong,Wu Xianghui,et al.A Double-blind Study of Hepatic Regenerative Stimulus (HRS) on Advanced Viral Hepatitis:Analysis of 318 Cases[J].Chinese Journal of Experimental and Clinical Virology,1995(1).
Authors:Xu Jazhag  Ju Jiulong  Wu Xianghui  
Abstract:The effects of HRS derived from newborn calves on patients with advanced viral hepatitis (AVH) were observed.The results showed that the total survival rate were 69.2% (220/318) in the HRS treatment group and 30.3% (33/109) in the control group.Among the 318 cases of patients with AVH,the survival rates were 69.9% in 73 cases of double-blind HRS group.71.4% in the randomized HRS group and 68.2% in 192 cases of 42 cases of un-controled HRS group.It is suggested that HRS could largely elevate the survival rate of the patients with AVH.
Keywords:Hepatic regenerative stimulus  Advanced viral hepatitis  Double-blind study  
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