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Expression and function of C1q receptors and C1q binding proteins at the cell surface |
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| Authors: | Ghiran Ionita Tyagi Shiv-Raj Klickstein Lloyd B Nicholson-Weller Anne |
| Affiliation: | aHarvard-Thorndike Laboratory of Beth Israel Deaconess Medical Center, Divisions of Allergy, Inflammation and Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA bDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA |
| Abstract: | C1q is the recognition unit of the first component of complement that binds not only IgG and IgM containing immune complexes, but also recognizes foreign structures such as the lipid A of endotoxin, and molecules expressed at the surface of apoptotic cells. In this review, the plasma membrane receptors and binding proteins for C1q are discussed and new data are presented on calreticulin expression on human peripheral blood cells. Although much is known about C1q receptors and binding molecules there are still many questions regarding their role in vivo. |
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