2型糖尿病伴发肾结石的危险因素

目的 分析2型糖尿病伴发肾结石患者的临床特征,探讨2型糖尿病伴发肾结石的相关危险因素.方法 采用回顾性分析方法,测定2型糖尿病伴肾结石组患者（60例）与2型糖尿病不伴肾结石组患者（60例）的空腹血糖（FPG）、糖化血红蛋白（HbA1c）、血清胰岛素、c肽、尿酸（UA）、甘油三脂（TC）、总胆固醇（TC）、低密度胆固醇（LDL-C）水平,计算胰岛素抵抗指数（Homa-IR）,统计分析两组患者上述指标结果差异性.结果 2型糖尿病伴肾结石组患者FPG（11.4±5.4） mmol/L、HbA1c％（9.5±2.7）、空腹血清胰岛素（10.5±6.2）mIU/L、空腹c肽（3.5±2.3） nmol/L、UA（377.1±119.3） mmol/L、TC（5.6±2.1） mmol/L、LDL-C（5.5±3.9）mmol/L、Homa-IR（5.1±3.7）,上述指标水平较2型糖尿病不伴肾结石组显著性升高（P值分别为0.035,0.026,0.017,0.004,0.048,0.037,0.022,0.029,均小于0.05）.结论 胰岛素抵抗、高血糖、高尿酸、脂代谢紊乱可能是2型糖尿病伴发肾结石的危险因素.

The risk factors of type 2 diabetes associated with renal calculus

Objective To analyze the clinical features and risk factors of patients with type 2 diabetes （T2DM） and renal calculus.Methods Fasting plasma glucose （FPG）,glycosylated hemoglobin （HbA1c）,serum insulin,c peptide,uric acid,triglyceride,total cholesterol,low-density cholesterol and insulin resistance index in 60 cases of T2DM with renal calculus and 60 cases of T2DM without renal calculus were measured and statistically analyzed.Results The levels of FPG,HbA1c,serum insulin,c peptide,UA,TC,LDL-C and Homa-IR of T2DM patients with renal calculus were （11.4 ± 5.4）mmol/L,（9.5 ± 2.7）％,（10.5 ± 6.2） mlU/L,（3.5 ± 2.3）nmol/L,（377.1 ± 119.3）mmol/L,（5.6 ± 2.1）mmol/L,（5.5 ± 3.9）mmol/L and （5.1 ± 3.7） respectively,significantly higher than those of T2DM patients without renal calculus （P ＜ 0.05）.Conclusions Insulin resistance,hyperglycemia,high uric acid and disorder of lipid metabolism may be risk factors of T2DM associated with renal calculus.