脑钠肽测定在慢性心力衰竭诊治中的临床价值

目的探讨脑钠肽（BNP）~N定在慢性心力衰竭诊治中的临床价值。方法选取本院2011年12月～2013年2月诊治的慢性心力衰竭患者71例为观察组，选取本院同期健康体检者70例为对照组，均行BNP测定．比较两组BNP水平，分析观察组BNP水平与心功能分级、超声心动图相关参数的关系。结果观察组BNP水平明湿高于对照组，差异有统计学意义（P〈O．05）。观察组心功能Ⅲ级BNP水平明显高于心功能Ⅱ级，心功能Ⅳ级BNP水平明显高于心功能Ⅱ、Ⅲ级；观察组左心室射血分数〈50％的BNP水平明显高于左心室射血分数≥50％，左心室舒张末期内径≥50mm的BNP水平明显高于左心室舒张末期内径〈50mm，左心房内径≥35mm的BNP水平明显高于左心房内径〈35mm，差异有统计学意义（P〈O．05）。结论慢性心力衰竭患者BNP水平显著升高，心功能分级越严重，BNP水平越高。

Clinical value of brain natriuretic peptide in diagnosis and treatment of chronic heart failure

Objective To investigate clinical value of brain natriuretic peptide （BNP） in diagnosis and treatment of chronic heart failure.Methods 71 patients with chronic heart failure were selected in our hospital from December 2011 to February 2013 as observation group.70 cases with physical examination were selected at same period in our hospital as control group.All cases underwent BNP measurement.BNP level of two groups was compared.Relationship of BNP level and cardiac function classification,echoeardiographic parameters in observation group were analyzed.Results BNP level of observation grou~＇~ was significantly higher than that of control group,with statistical difference （P〈0.05）.BNP level in cardiac functional class Ⅲ was significantly higher than that of cardiac functional class Ⅱ in observation group,BNP level in cardiac functional class Ⅳ was significantly higher than that of cardiac functional classⅡand Ⅲ in observation group,with statistical difference （P〈0.05）.BNP level of LVEF〈50% group was significantly higher than that of LVEF ≥ 50% group in observation group,BNP level of LVDD t〉 50 mm group was significantly higher than that of LVDD 〈50 mm group in observation group,BNP level of LADD ≥ 35 mm group was significantly higher than that of LADD〈35 mm group in observation group,with statistical difference （P〈0.05）. Conclusion BNP level in patient with chronic heart failure can significantly increase.Classification of cardiac function is more serious,BNP level is higher.