热休克蛋白27及ER在子宫内膜腺癌中的表达及意义

目的：检测热休克蛋白（HSP）27及ER在正常子宫内膜、增生过长子宫内膜、非典型增生和子宫内膜腺癌中的表达情况，探讨其临床病理学意义及其与子宫内膜腺癌发生、发展的关系。方法：采用免疫组织化学SP法检测16例正常子宫内膜、8例增生过长子宫内膜、8例非典型增生子宫内膜、45例子宫内膜腺癌中HSP27和ER的分布及表达。结果：HSP27在子宫内膜腺癌组织中的表达低于前三种状态的子宫内膜，差异均有统计学意义（P〈0．05）；ER在子宫内膜腺癌组织中的表达也低于前三种状态的子宫内膜，与增生过长子宫内膜、非典型增生子宫内膜比较，差异有统计学意义（P〈0．05）。HSP27在子宫内膜腺癌的不同病理学分级之间的表达差异有统计学意义（P〈0．05）；但在不同年龄组、手术一病理分期、肌层浸润之间差异无统计学意义（P〉0．05）。子宫内膜中HSP27表达与ER表达呈正相关（rsE0．956．P〈0．01）。结论：HSP27在子宫内膜腺癌中的表达可能与子宫内膜腺癌的发生、发展有关。

Expression and significance of heat shock protein 27 and ER in endometrial adenocarcinoma

Objective： To explore the expression and clin-pathologie significance of heat shock protein （HSP） 27 and ER in endometrial adenecarcinoma. Methods： Expressions of HSP27 and ER in 16 normal endometrium, 8 hyperplastie endometrium, 8 atypical hyperplastic endometrium and 45 endometrial adenocarcinoma were detected by immunohistochemical staining SP method. Results： The expression of HSP27 in endometrial adenocarcinoma was significantly lower than that in normal endometrium, hyperplastic endometrium and atypical hyperplasia endometrium （P〈0.05）. The expression of ER in endometrial adenocarcinoma was also significantly lower than that in hyperplastic endometrium and atypical hyperplasia endometrium （P〈0.05）. Expression of HSP27 decreased with increased pathological grading of tumor （P〈0.05）. There was no correlation among expression of HSP27 in endometrial adenocarcinoma and age, stage and depth invaded into muscular layer （P〉0.05）. Expression of HSP27 had direct correlation with the expression of ER in endometrium（rs=0.956, P〈0.01）. Conclusion： HSP27 may have relation to the genesis and prognosis of endometrial carcinoma.