药物浓度和病因对三磷酸腺苷治疗阵发性室上性心动过速的影响

本文报告23例次ATP治疗PSVT的效果,总有效率56.5％,9例次高浓度快速注射者8例转复。器质性心脏病者副作用较多,1例冠心速注高浓度ATP后,发生心室颤动和阿-斯氏综合征。这一结果提示:药物浓度和注射速度是影响疗效的主要因素,PSVT伴AVB者疗效也很低;病因和药物浓度是决定副作用的因素。因此,对于器质性心脏病者,尤其冠心病人,应避免高浓度快速静脉注射ATP。

THE INFLUENCE OF DRUG CONCENTRATION AND ETIOLOGY ON TREATMENT OF PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA WITH ADENOSINE TRIPHOSPHATE

This paper reports the results of the treatment of 23 cases of PSVT by ATP. The total effective rate was 56.5%. Expected effectiveness was achieved in 8 among 9 cases Who were treat- ed with high concentration ATP by rapid iv injection. The side-effect was more common in patients with organic heart disease. In a patient with cor- onary heart disease there occurred Ventricular fibrillation and Adams-Stokes syndrome after the rapid injection of high concentration ATP. These results indicate; drug concentration and speed of injection are essential factors of effective rate; the therapeutic effect is lower in patients with PSVT accom- pauied with AVB; etiology and drug concentration are determinant for Side- effect. Therefore, the patient with organic heart disease, especially with co- ronary heart disease Should avoid being quickly injected with high concent- ration ATP.