重组人生长激素治疗青春期前特发性矮小症60例疗效分析

【目的】探讨重组人生长激素（recombinant human growth hormone，rhGH）对青春期前特发性矮小症（Idiopathic short stature，ISS）儿童促身高增长的疗效。【方法】经胰岛素和左旋多巴药物联合激发试验测定生长激素（GH）确诊缺乏的ISS儿童60例，每晚睡前皮下注射rhGH治疗0．15IU／（kg．d），疗程6个月，并对其疗效进行一年的观察。【结果】ISS患儿经生长激素治疗后，生长速率（．growt h velocity，GV）由治疗前测量的（3．61士0．42）cm／年提高到治疗后（7．69±3．31）cm／年，差异有显著性（P〈0．05）。身高由治疗前（134．12±14．14）cm提高到治疗后（141．20±13．88）cm，差异有显著性（P〈0．05）。治疗期间除少数肝功能轻度异常，有6例儿童在注射部位出现一过性红肿，双下肢轻度水肿和过敏性皮疹等，但未予处理后自行消失，另未发现其他明显副作用。【结论】皮下注射rhGH对治疗儿童ISS有增快生长速度作用，疗效肯定，是一种安全有效的方法，值得儿科临床推广应用。

Analysis of the Efficacy of Recombinant Human Growth Hormone for the Treatment of Idiopathic Short Stature Before Puberty

[Objective]To explore the effect of gene recombinant human growth hormone（rhGH） for improving the growth in stature in children with idiopathic short stature（ISS）. [Methods] Sixty ISS children diagnosed by provocative test with insulin and levodopa for measuring growth hormone（GH） deficiency were given subcutaneous injection of rhGH 0.15IU/（kg. d） before sleep every night for 6 months. The efficacy was observed for a year. [ResultsiAfter GH treatment for ISS children, the growth velocity（GV） increased from （3.61±0.42） cm/year before treatment to （7.69 ±3.31 ）cm/year after treatment, and there was significant difference（ P〈0.05）. The body height also increased from （ 134.12±14.14 ） cm before treatment to （ 141.20 ±13.88 ）cm after treatment, and there was significant difference（ P〈0.05）. During the treatment, a few patients had mildly abnormal liver function, and 6 patients had transient flare in the injection site, mild edema of both lower limbs and allergic skin rash, and these symptoms disappeared without treatment. Other obvious side effects were found. [Conclusion] rhGH subcutaneous injection for the treatment of ISS children can improve the GV and has certain efficacy. Therefore it is a safe and effective method, and worthy of clinical applieation in pediatrics.