|
|||||
|
|
| 转录因子NF-E2相关因子2信号通路在金属污染物毒理学作用中的机制及其研究进展 | |
| 引用本文： | 陈嘉兴,吴礼康,田亚锋,鲜敏,余日安. 转录因子NF-E2相关因子2信号通路在金属污染物毒理学作用中的机制及其研究进展[J]. 环境与健康杂志, 2017, 34(5). DOI: 10.16241/j.cnki.1001-5914.2017.05.025 |
| 作者姓名： | 陈嘉兴 吴礼康 田亚锋 鲜敏 余日安 |
| 作者单位： | 1. 广东药科大学公共卫生学院,广东广州,510310;2. 深圳市宝安区疾病预防控制中心 |
| 摘 要： | 镉、铅和砷等重金属和类金属是重要的环境污染物,金属污染物引起的氧化应激是其引起健康损害的重要毒理学机制。转录因子NF-E2相关因子2(nuclear factor E2 related factor 2,Nrf2)信号通路是细胞抗氧化应激的中枢调节者,在细胞介导的抗氧化应激防御反应中具有重要作用。本研究主要介绍了镉、铅和砷对Nrf2信号通路的作用及其机制,并综述了锌、铬、铜在毒理学作用中对Nrf2信号通路的影响。 |
| 关 键 词： | 转录因子NF-E2相关因子2 金属污染物 氧化应激 |
Role of transcription factor NF-E2-related factor 2 signaling pathway in toxicity of metal pollutants: a review of recent studies |
|
| CHEN Jia-xing,WU Li-kang,TIAN Ya-feng,XIAN Min,YU Ri-an. Role of transcription factor NF-E2-related factor 2 signaling pathway in toxicity of metal pollutants: a review of recent studies[J]. Journal of Environment and Health, 2017, 34(5). DOI: 10.16241/j.cnki.1001-5914.2017.05.025 | |
| Authors: | CHEN Jia-xing WU Li-kang TIAN Ya-feng XIAN Min YU Ri-an |
| Abstract: | Cadmium,lead,arsenic and other heavy metals and metalloids are important environmental pollutants.Oxidative stress caused by metal pollutants is an important toxicological mechanism.The studies demonstrate that Nrf2 signal pathway is a central regulator of cellular anti-oxidative stress,which plays an important role in the defense response of cell mediated antioxidative stress.This paper mainly introduced the effects and mechanisms of cadmium,lead and arsenic on Nrf2 signal pathway,and briefly summarized the effects of zinc,chromium and copper on the Nrf2 signaling pathway in the process of toxic effects. |
| Keywords: | Nuclear factor E2 related factor 2 Metal pollutants Oxidative stress |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |