乌司他丁联合胸腺肽治疗重症肺炎患者临床效果分析

目的 探讨乌司他丁联合胸腺肽治疗重症肺炎患者的临床效果.方法 选择2018年5月至2019年5月我院收治的重症肺炎患者8 6例为研究对象,采用随机数字法分为两组,每组4 3例.对照组患者给予常规治疗,观察组患者在对照组患者治疗的基础上给予乌司他丁及胸腺肽治疗,疗程10 d.比较两组患者治疗前后的动脉血气分析结果、炎症指...

Ulinastatin combined with thymosin in the treatment of patients with severe pneumonia:an analysis of the clinical effect

Objective To investigate the clinical effect of ulinastatin combined with thymosin in the treatment of severe pneumonia.Methods A total of 86 patients with severe pneumonia admitted to our hospital from May 2018 to May 2019 were selected as the research objects,and they were assigned to two groups according to the random number method,with 43 cases in each group.The control group was given conventional treatment,based on which the observation group was given ulinastatin combined with thymosin for treatment,for a ten-day course of treatment.The pre-and post-treatment results of arterial blood gas analysis,inflammatory index levels,and acute physiology and chronic health evaluationⅡ(APACHEⅡ)system score were compared between the two groups.Results Before treatment,there were no statistically significant differences in the arterial partial pressure of oxygen(PaO₂),partial pressure of carbon dioxide in arterial blood(PaCO₂)and arterial oxygen saturation(SaO₂)between the two groups(P>0.05).After 10 days of treatment,the levels mentioned above significantly increase,and the observation group yielded significantly higher levels as compared with the control group,with statistically significant differences(P<0.05).Before treatment,there were no statistically significant differences in the levels of procalcitonin,C-reactive protein(CRP),serum amyloid-A(SAA)and interleukin 6(IL-6)between the two groups(P>0.05).After 10 days of treatment,the levels mentioned above significantly decreased,and the levels of the observation group were significantly lower than those of the control group,with statistically significant differences(P<0.05).Before treatment,there was no statistically significant difference in the APACHEⅡscore between the two groups(P>0.05).After 10 days of treatment,the APACHEⅡscore of the two groups significantly decreased,and the observation group yielded a lower score compared with the control group,with statistically significant differences(P<0.05).Conclusion On the basis of conventional treatment,additionally administration of ulinastatin and thymosin in treating patients with severe pneumonia can effectively improve the respiratory function,significantly decrease the levels of inflammatory factors,significantly alleviate the condition,and improve the prognosis,which is worthy of promotion and application.