可调式负压引流联合臭氧水治疗感染性创面的临床研究

目的探讨工作不同模式和压力的间断负压引流联合臭氧水冲洗治疗与促进感染性创面抗炎修复的临床相关性影响。方法选取2017年1月至2019年11月本院收治的临床感染性创面患者150例,经过清创手术后随机分为5组,每组30例。A组为长间断低负压引流联合臭氧水冲洗治疗组,B组为长间断中负压引流联合臭氧水冲洗治疗组,C组为短间断低负压引流联合臭氧水冲洗治疗组,D组为短间断中负压引流联合臭氧水冲洗治疗组,E组为对照组。观察5组患者治疗10 d后全身炎性指标、疼痛评分及创面的局部情况。结果治疗10 d后,E组平均愈合率(30.1±6.2)%,感染率为23.3%;A组平均愈合率(46.3±11.2)%,感染率为13.3%;B组平均愈合率(40.7±8.7)%,感染率为10.0%;C组平均愈合率(50.5±12.3)%,感染率0%;D组平均愈合率(48.9±9.6)%,感染率0%。C组短间断低负压引流联合臭氧水冲洗治疗组创面愈合率最高,感染率最低,E组愈合率最低、感染率最高;疼痛评分由高到低依次为E组、B组、D组、A组和C组,组间比较差异有统计学意义(P<0.05)。治疗10 d后,5组患者血浆白细胞计数、CRP(C反应蛋白)水平比较差异有统计学意义(P<0.05)。结论可调式负压引流联合臭氧水可降低感染性创面患者的炎性指标,控制感染,缩短愈合时间,提高感染性创面愈合率,且短间断低负压引流联合臭氧水治疗效果更好。

Clinical study of adjustable negative pressure drainage combined with ozone water in the treatment of infectious wounds

Objective To explore the effect of intermittent negative pressure drainage combined with ozone water washing in different working modes and pressures on the anti-inflammatory repair of infectious wounds.Methods 150 patients with clinical infective wound were randomly divided into 5 groups after debridement from January 2017 to November 2019,with 30 cases in each group.Group A was treated with intermittent low negative pressure drainage combined with ozone water washing,group B was treated with intermittent middle negative pressure drainage combined with ozone water washing,group C was treated with intermittent low negative pressure drainage combined with ozone water washing treatment group,group D:intermittent middle negative pressure drainage combined with ozone water washing and group E was the control group.After 10 days of treatment,the systemic inflammatory index,pain score and local condition of wound were observed.Results After 10 days of treatmen,the average healing rate was(30.1±6.2)%and the infection rate was 23.3%in group E,the average healing rate was(46.3±11.2)%,and the infection rate was 13.3%.in group A.In group B,the average healing rate was(40.7±8.7)%and the infection rate was 10.0%.In group C,the average healing rate was(50.5±12.3)%and the infection rate was 0%,the average healing rate was(48.9±9.6)%and the infection rate was 0%in group D.In group C,the wound healing rate was the highest and the infection rate was the lowest,while in group E,the wound healing rate was the lowest and the infection rate was the highest.The pain score was arranged from high to low in group E,group B,group D,group A and group C,the difference was statistically significant(P<0.05).There was significant difference in the level of plasma leukocyte count and CRP after 10 days of treatment(P<0.05).Conclusion Adjustable negative pressure drainage combined with ozone water can reduce the inflammatory index of patients with infectious wound,control the infection,shorten the healing time,improve the healing rate of infectious wounds,and short-term intermittent low negative pressure drainage combined with ozone water is better.