偶发性前列腺癌的临床病理学研究

目的:探讨偶发性前列腺癌的临床病理特征及预后.方法:回顾性分析580例膀胱癌根治术中96例偶发前列腺癌的临床资料及病理学特征,并进行预后随访.结果:偶发前列腺癌的发生率为16.6％(96/580).年龄42～90岁,中位年龄为73岁;其中≤60岁6例(6.2％),＞60岁90例(93.8％).肿瘤平均最大直径约3.5 ...

Incidental prostate cancer:A clinicopathological study

Objective:To investigate the clinicopathological characteristics and prognosis of incidental prostate cancer(PCa).Methods:We retrospectively analyzed the clinical data and pathological characteristics of 96 cases of incidental PCa in 580 patients undergoing radical cystectomy and followed them up for prognosis.Results:The incidence rate of incidental PCa was 16.6%(96/580).The patients were 42-90 years old,with a median age of 73 years,6(6.2%)≤60 and 90(93.8%)over 60 years old.The average maximum diameter of the tumor was about 3.5 cm(range 1.0-9.0 cm).Histologically,86(89.6%)of the bladder cancer cases were high-grade invasive urothelial carcinoma(7 with squamous differentiation,2 with sarcomatoid differentiation,4 with glandular differentiation,and 1 with plasmacytoid/diffuse variant)and 7 were low-grade urothelial carcinoma,of which 1 case was poorly differentiated neuroendocrine carcinoma and 2 cases were bladder adenocarcinoma,including 1 case of signet ring cell carcinoma.All the PCa cases were classified as the histopathological type of classic acinar adenocarcinoma of the prostate,67(69.8%)with a Gleason score≤6,and 29(30.2%)with a Gleason score≥7.Of the total number of incidental PCa cases,32(33.3%)were of clinical significance,and 59(61.5%)of the patients were followed up for 1-95(mean 28.7)months,during which 42(71.2%)survived and 17(28.8%)died,including 2 deaths due to non-cancer factors.No statistically significant difference was found in the median survival time between the 5 clinically significant and 10 non-clinically significant cases(P=0.322).Conclusion:There is a high probability of incidental PCa among bladder cancer patients aged>60 years.Standardized sampling plays an important role in detection of the malignancy.There is only a small proportion of incidental PCa cases with clinical significance,and therefore it affects less the prognosis than bladder cancer.