妊娠期肝内胆汁淤积症羊水性状与妊娠结局的关系

目的探讨妊娠期肝内胆汁淤积症（ICP）羊水性状与妊娠结局的关系。方法对452例住院分娩的ICP患者资料进行回顾性分析，统计羊水污染率、新生儿窒息率、围生儿死亡率及剖宫产率等。结果452例ICP中轻度326例，重度126例。羊水污染124例（ICP羊水Ⅱ级44例，ICP羊水Ⅲ级80例），重度ICP的羊水污染率为72．22％。9例围生儿死亡中8例为ICP羊水Ⅲ级，124例ICP羊水Ⅱ级及Ⅲ级病例中出现22例新生儿窒息。未正式临产及胎膜早破而在34周后行剖宫产终止妊娠的302例ICP，术中发现羊水污染的有72例。结论ICP的羊水性状与病情程度基本一致，羊水污染预示着不良的妊娠结局，适时终止妊娠可降低围生儿发病率。

Relationship between outcome of pregnant and character of amniotic fluid in intrahepatic cholestasis of pregnancy

Objective To study the relationship between the prognosis of mother and fetus and the character of amniotic fluid in intrahepatic cholestasis of pregnancy （ICP）. Methods 452 pregnant women with ICP were analyzed. The amniotie fluid pollution, fetal distress, perinatal mortality and cesarean delivery rates were observed. Results There were 124 pregnant women with amniotic fluid pollution,including 91 cases with severe ICP and 22 cases with fetal distresses. In 9 perinatal deaths, there were 8 women with m degree of amniotic fluid. There were 72 cases with amniotic fluid pollution of 302 patients. Conclusion The character of amniotic fluid is consistent with severity of ICP.