VEGF-C和VEGF-R3在非小细胞肺癌中的表达及其意义

目的　探讨VEGF C及其受体VEGF R3与非小细胞肺癌患者临床病理特征之间的关系。方法　采用免疫组化方法 ,检测 84例非小细胞肺癌组织中VEGF C及VEGF R3表达 ,将表达结果与临床病理特征及预后进行统计学分析。结果　VEGF C和VEGF R3在肺癌细胞膜和细胞浆中高表达 (阳性率分别为5 5 .9%和 5 9.5 % ) ,而在癌旁肺组织中无表达。VEGF C表达与病理类型有密切关系 (P =0 .0 13 ) ;VEGF R3表达与淋巴结转移状况 (P =0 .0 0 2 )及TNM分期 (P =0 .0 2 0 )有密切关系。多因素分析表明 ,VEGF R3 (P <0 .0 0 1)和病理类型 (P =0 .0 2 0 )是影响预后的独立危险因素。结论　检测肺癌组织中VEGF R3表达有助于预测非小细胞肺癌患者预后。

Expression of vascular endothelial growth factor C and its receptor VEGF-R3 and their significance in non-small cell lung cancer

Objective To determine the relationship between VEGF-C/VEGF-R3 expression and clinicopathologic factors and prognosis of patients with non-small cell lung cancer (NSCLC). Methods VEGF-C and VEGF-R3 expression was detected in 84 patients with NSCLC by immunohistochemical staining. The significance of VEGF-C and VEGF-R3 expression was analyzed statistically. Results In the immunoreactive cells, staining was mainly located in cytoplasm and membrane. VEGF-C and VEGF-R3 were highly expressed in lung cancer tissues (55.9% and 59.5%, respectively) while negative in the normal lung tissues. The expression of VEGF-C significantly correlated with histology (P=0.013). VEGF-R3 expression was associated with lymph node metastasis (P=0.002) and TNM stage (P=0.020). Multivariate analysis showed that VEGF-R3 (P<0.001) and histology (P=0.020) were independent prognostic factors. Conclusion Detection of VEGF-R3 in lung cancer tissues might be helpful to predict prognosis of patients with lung cancer.