多西他赛与顺铂联合行不同化疗途径对宫颈癌的实效性对照探究

目的 观察并探讨多西他赛(Docetaxel,DCT)与顺铂(Cisplatin,CDDP)联合行不同化疗途径对宫颈癌(cervical cancer,CC)的有效性和安全性。 方法 宁波市第一医院于2010年5月—2014年7月期间对确诊为CC的90例患者实施化疗，其中45例接受DCT联合CDDP静脉化疗，为对照组，另外45例采用DCT联合CDDP动脉灌注化疗(arterial infusion chemotherapy,AIC)，作为观察组。评价2组患者的近期疗效，并随访化疗后宫旁缓解、化疗后手术、中心复发以及不良反应发生情况。 结果 观察组有效率为91.1%(41/45)，对照组为80.0%(36/45)，观察组有效率明显高于对照组(P＜0.05)；观察组化疗后宫旁缓解率、化疗后手术率、中心复发率分别为82.2%(37/45)、75.6%(34/45)和4.4%(2/45)，对照组为66.7%(30/45)、73.3%(33/45)和4.4%(2/45)，观察组化疗后宫旁缓解率明显高于对照组，而2组一年内化疗后手术率及中心复发率相比，差异无统计学意义(P＞0.05)；观察组骨髓抑制、胃肠道反应、神经毒性发生率明显低于对照组(P＜0.05)。 结论 DCT联合CDDP的动脉灌注化疗治疗CC具有良好的近期疗效，且不良反应发生率均更低，是CC较为安全有效的疗法。 

Effectiveness of docetaxel combined with cisplatin by different approach on cervical carcinoma

Objective To observe the effect of effectiveness and safety of docetaxel(DCT) combined with cisplatin(CDDP) by different approach in the treatment of cervical carcinoma(CC). Methods Total 90 patients with CC in our hospital between May,2010 and July,2014 were selected,45 patients received DCT combined with CDDP chemotherapy were as the control group,while 45 cases received DCT combined with CDDP arterial infusion chemotherapy(AIC) were as the observation group.The effect was evaluated after the treatment,and the remission of parametrial invasion,salvage surgery after chemotherapy,postoperative recurrence as well as adverse reactions were followed up. Results The efficacy in the observation group was 91.1%(41/45),while in the control group was 80.0% (36/45),the difference was significant(P<0.05);the remission rate after the chemotherapy,postoperative chemotherapy rate,postoperative recurrence in the observation group were 82.2%(37/45),75.6%(34/45) and 4.4%(2/45),while in the control group was 66.7%(30/45),73.3%(33/45) and 4.4%(2/45),the remission rate after the chemotherapy in the observation group was significantly higher as compared with the control group,while the difference in the postoperative chemotherapy rate,postoperative recurrence was not statistically significant(P>0.05);the incidence of bone marrow suppression,gastrointestinal reactions,neurotoxicity was significantly lower in the observation group than that in the control group(P<0.05). Conclusion DCT combined with CDDP chemotherapy in the treatment of CC has a good short-term efficacy,and the incidence rate of adverse reactions is lower,it is a safe and effective treatment for CC.