| 银杏叶提取物诱导骨髓间充质干细胞成骨分化过程中P38信号通路的研究 |
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| 引用本文： | 时舒曼,袁浩天,张晓晓,吴哲. 银杏叶提取物诱导骨髓间充质干细胞成骨分化过程中P38信号通路的研究[J]. 口腔医学研究, 2016, 32(9): 912. DOI: 10.13701/j.cnki.kqyxyj.2016.09.005 |
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| 作者姓名： | 时舒曼 袁浩天 张晓晓 吴哲 |
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| 作者单位： | 1. 吉林大学口腔医学院修复科 吉林 长春 130021;2. 中国人民解放军208医院 吉林 长春 130000;3. 广州医科大学附属口腔医院 广东 广州 510500 |
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| 基金项目： | 吉林省产业技术研究与开发项目(编号:2013C023-5) |
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| 摘 要： | ![]()
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| 关 键 词： | 银杏叶提取物 骨髓间充质干细胞 P38MAPK信号通路 成骨分化 |
| 收稿时间： | 2016-01-07 |
Ginkgo Biloba Extract Promotes Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells in a Pathway Involving P38 MAPK Signaling Pathway |
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| SHI Shu-man,YUAN Hao-tian,ZHANG Xiao-xiao,WU Zhe. Ginkgo Biloba Extract Promotes Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells in a Pathway Involving P38 MAPK Signaling Pathway[J]. Journal of Oral Science Research, 2016, 32(9): 912. DOI: 10.13701/j.cnki.kqyxyj.2016.09.005 |
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| Authors: | SHI Shu-man YUAN Hao-tian ZHANG Xiao-xiao WU Zhe |
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| Affiliation: | 1. Department of Prosthodontics, School of Stomatology, Jilin University, Changchun 130021, China;2. Chinese PLA 208 Hospital, Changchun130000, China;3. Stomatology School of Guangzhou Medical University, Guangzhou 510500, China |
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| Abstract: | ![]()
Objective: To reveal the mechanism of GBE promoting osteogenic differentiation of rat BMSCs. Methods: 150mg/L GBE was applied to the third generation of rat BMSCs, while the inhibitor group underwent a pretreatment of SB203580, which was the specific inhibitor of P38 MAPK signaling pathway. The results were evaluated by ARS dye, ALP activity assay and RT-PCR. Results: Statistically significant difference was found between the control group and the inhibitor group. In the inhibitor group, extracellular calcium deposition, ALP activity and the expression of osteogenic-related genes including ALP, BMP-2, OCN and Runx2 were lower than the control group. Conclusion: GBE promoted osteogenic differentiation of rat BMSCs by upregulating the P38 MAPK signaling pathway. |
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| Keywords: | Ginkgo biloba extract Bone marrow mesenchymal stem cells P38 MAPK signaling pathway Osteogenic differentiation |
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