带状疱疹后遗神经痛的发病相关因素分析

目的 探讨带状疱疹后遗神经痛发病的相关因素，为临床带状疱疹后遗神经痛的治疗提供依据。 方法 收集浙江省人民医院带状疱疹患者79例作为研究对象，根据是否有后遗神经痛，分为带状疱疹后遗神经痛组29例和非带状疱疹后遗神经痛组50例。对79例患者进行问卷调查，记录并分析带状疱疹类型、就诊时间、皮肤受累面积、有无前驱疼痛与后遗神经痛的关系。 结果 带状疱疹就诊时间和带状疱疹后遗神经痛的发病率有显著相关性(P＜0.05)，在5 d内就诊的带状疱疹患者发生带状疱疹后遗神经痛的比例为13.3%，就诊时间超过5 d的带状疱疹患者发生带状疱疹后遗神经痛的比例为42.2%，5 d以上就诊患者带状疱疹后遗神经痛的发生率明显增加；带状疱疹的皮肤受累面积和带状疱疹后遗神经痛的发病率有显著相关性(P＜0.05)，带状疱疹皮肤小面积受累时带状疱疹后遗神经痛的发生率为25.0%，带状疱疹皮肤大面积受累时带状疱疹后遗神经痛的发生率为51.4%，带状疱疹受累面积大时后遗神经痛的发生率增加；带状疱疹前驱疼痛和带状疱疹后遗神经痛的发病率有显著相关性(P＜0.05)，带状疱疹有前驱疼痛时，带状疱疹后遗神经痛的发生率为47.9%，带状疱疹无前驱疼痛时，带状疱疹后遗神经痛的发生率为19.4%，有前驱疼痛时带状疱疹后遗神经痛的发生率明显高于无前驱疼痛时带状疱疹后遗神经痛的发生率(P＜0.05)。 结论 带状疱疹后遗神经痛的发生率和带状疱疹的类型无关，和带状疱疹的就诊时间、皮肤受累面积和前驱疼痛相关。 

Analysis of related factors with postherpetic neuralgia

Objective To study the risk factors of postherpetic neuralgia,and provide the basis for the clinical treatment. Methods Total 79 cases patients with herpes zoster in our hospital were recricted and divided into postherpetic neuralgia group(29 cases) and non-postherpetic neuralgia group(50 cases).A questionnaire survey was conducted among all patients.The shingles type,treatment time,the invloved area ofskin,prodromalpain and the correlation with postherpetic neuralgia were recorded and anlyzed. Results The treatment time for herpes zoster and the incidence of postherpetic neuralgia was significantly correlated(P<0.05),the incidence of post-herpetic neuralgia less than five days of treatment was 13.3 percent,the incidence of post-herpetic neuralgia more than five days of treatment was 42.2 percent,the incidence of postherpetic neuralgia less than 5 days of treatment was significantly higher than the incidence of postherpetic neuralgia more than 5 days of treatment;the involved area of skin of herpes zoster and the incidence of postherpetic neuralgia was significantly correlated(P<0.05).The incidence of post-herpetic neuralgia with a small area of the affected shingles was 25.0 percent,the incidence of post-herpetic neuralgia with a large area of the affected shingles was 51.4 percent,the incidence of postherpetic neuralgia with a large area of the affected shingles was significantly higher than the incidence of postherpetic neuralgia with a small area of the affected shingles;The prodromalpain of herpes zoster and the incidence of postherpetic neuralgia was significantly correlated(P<0.05),the incidence of post-herpetic neuralgia with prodromalpain was 47.9 percent,the incidence of post-herpetic neuralgia without prodromalpain was 19.4 percent,the incidence of postherpetic neuralgia with prodromalpain was significantly higher than the incidence of postherpetic neuralgia without prodromalpain. Conclusion The incidence of postherpetic neuralgia has no correlation with herpes zoster type,but significantly correlation with treatment time,the involved area of skin and prodromalpain.The active and effective early treatment can reduce the incidence of post-herpetic neuralgia.