| 缺氧对非酒精性脂肪性肝病发病的影响* |
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| 引用本文： | 管红雨(综述),蔡晓波,陆伦根(审校). 缺氧对非酒精性脂肪性肝病发病的影响*[J]. 实用肝脏病杂志, 2016, 19(2): 237-240. DOI: 10.3969/j.issn.1672-5069.2016.02.034 |
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| 作者姓名： | 管红雨(综述) 蔡晓波 陆伦根(审校) |
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| 作者单位： | 226230 江苏省启东市第五人民医院内科（管红雨）; 上海市第一人民医院消化内科（蔡晓波,陆伦根） |
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| 基金项目： | 天晴肝病研究基金资助项目（编号：030320） |
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| 摘 要： | 非酒精性脂肪性肝病（NAFLD）患者存在系统性和肝脏局部缺氧。对于呼吸睡眠暂停综合征与脂肪性肝病的研究显示机体缺氧程度与胰岛素抵抗、肝脏脂肪变、炎症和纤维化程度相关。动物实验和分子生物学研究显示缺氧及其缺氧诱导因子能促进肝细胞脂肪堆积,加速肝脏炎症、纤维化,甚至肿瘤的发生和发展。
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| 关 键 词： | 非酒精性脂肪性肝病 缺氧 缺氧诱导因子 |
| 收稿时间： | 2015-05-13 |
Hypoxia in the pathogenesis of nonalcoholic fatty liver diseases |
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| Guan Hongyu,Cai Xiaobo,Lu Lungen. Hypoxia in the pathogenesis of nonalcoholic fatty liver diseases[J]. Journal of Clinical Hepatology, 2016, 19(2): 237-240. DOI: 10.3969/j.issn.1672-5069.2016.02.034 |
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| Authors: | Guan Hongyu Cai Xiaobo Lu Lungen |
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| Affiliation: | Department of Internal Medicine,Fifth People’s Hospital, Qidong 226230,Jiangsu Provienc |
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| Abstract: | Systematic and local hypoxia in liver is common in patients with nonalcoholic fatty liver diseases （NAFLD）. Studies on the relationship between obstructive sleep apnea and NAFLD show that the extent of hypoxia is positively correlated with insulin resistance,liver steatosis,and hepatic inflammation and fibrosis. Experiments in animals and molecular researches demonstrate that hypoxia and the hypoxia-inducible factors could promote the occurrence and progression of hepatic steatosis,inflammation,fibrosis,and even induce carcinoma in liver. |
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| Keywords: | Nonalcoholic fatty liver disease Hypoxia Hypoxia-induced factor |
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