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“脑回形(cortex-like)”微弧氧化膜钛种植体成骨的Micro-CT分析
引用本文:周宏志,李亚达,刘唤,刘琳,王伟强,马国武,齐民. “脑回形(cortex-like)”微弧氧化膜钛种植体成骨的Micro-CT分析[J]. 口腔医学研究, 2016, 32(7): 676. DOI: 10.13701/j.cnki.kqyxyj.2016.07.003
作者姓名:周宏志  李亚达  刘唤  刘琳  王伟强  马国武  齐民
作者单位:1. 大连市口腔医院寺儿沟门诊部 辽宁 大连 116021;2. 大连理工大学材料与工程学院 辽宁 大连 116021;3. 大连医科大学口腔医学院 辽宁 大连 116021
基金项目:国家自然科学基金(编号:51371042);教育部博士点基金(编号:20130041110005);大连市科技局基金项目(编号:2014E14SF164)
摘    要:
目的: 利用Micro-CT评价“大脑皮质”(cortex-like)形貌的二氧化钛膜层在初始稳定性和继发稳定性阶段的骨-种植体结合的能力。方法: 实验组MAO(cortex-like)为 “大脑皮质”形貌种植体,对照组SLA为具有同等规格的SLA形貌的种植体,共计36颗,通过扫描电镜(SEM)等对材料表面进行表征,随机植入18只新西兰雄性兔的股骨髁部,分别于4周和8周处死取样,所得标本行Micro-CT扫描重建,分析MAO和SLA种植体表面的骨结合状况以及的骨小梁形态学参数。结果: 类“大脑皮质”形貌氧化层由微米级沟槽和纳米级孔洞组成,沟槽相互交通,接触角(6.9±1.14)°,Micro-CT检测可见:随着骨结合时间的延长,骨体积分数(BV/TV)、骨小梁数量(Tb.N)、厚度(Tb.Th)、连接密度增加(Conn.Dn)均增加,结构模型指数(SMI)、骨小梁分离度(Tb.Sp)下降,第4周时,BV/TV,SMI组间比较差异存在统计学意义(P<0.05),第8周时,BV/TV、Tb.N、Tb.Sp、Conn.Dn值组间比较差异存在统计学意义(P<0.05),MAO高于SLA组。结论: “大脑皮质”(cortex-like)形貌的二氧化钛、具有双微层结构膜层,能促进种植体的骨结合的提升,是一种良好的种植体改性方法。

关 键 词:钛种植体  微弧氧化  大脑皮质形貌  Micro-ct  骨小梁  
收稿时间:2015-12-14

Micro-CT Analysis of Osseointegration of Cortex-like Titania Implant Coatings with Micro-arc Oxidation.
ZHOU Hong-zhi,LI Ya-da,LIU Huan,LIU Lin,WANG Wei-qiang,MA Guo-wu,QI Min. Micro-CT Analysis of Osseointegration of Cortex-like Titania Implant Coatings with Micro-arc Oxidation.[J]. Journal of Oral Science Research, 2016, 32(7): 676. DOI: 10.13701/j.cnki.kqyxyj.2016.07.003
Authors:ZHOU Hong-zhi  LI Ya-da  LIU Huan  LIU Lin  WANG Wei-qiang  MA Guo-wu  QI Min
Affiliation:1. Siergou Outpatient Department, Stomatological Hospital of Dalian, Dalian 116021, China; 2. Materials and Engineering College, Dalian University of Technology, Dalian 116021, China; 3. Hospital of Stomatology, Dalian Medical University, Dalian 116021, China
Abstract:
Objective: To assess the osseointegration of porous titania (TiO2) coating with a novel cortex-like morphology by micro-CT. Methods: Cortex-like morphology Ti surface was produced by MAO, and SLA surface was used as control.The surface features were evaluated by scanning electron microscope (SEM) and contact Angle. Thirty-six threaded implants were placed in the femoral condyles of 18 male New Zealand White rabbits. Trabecular bone morphology parameters were analyzed after implantation 4 weeks and 8 weeks by Micro-CT. Results: Morphology microstructure of MAO cortex-like was composed of microscale and nanoscale structure, with better wettability and contact Angle (6.9±1.14)°. Along with the time of bone healing, the BV/TV, Tb. N, Tb. Th and Conn. Dn were increased, while SMI and Tb. Sp were decreased. At 4th week, statistical significances were detected in BV/TV and SMI (P<0.05). At 8th week, statistical significances were detected in BV/TV, Tb. N, Tb. Sp and Conn.Dn (P<0.05). Cortex-like morphology exhibited more continuous bone apposition. Conclusion: The cortex-like morphology of titanium with microscale and nanoscale topologic structure can improve the osseointegration of Ti implant and has good biocompatibility.
Keywords:Titanium implant   Micro-arc oxidation   Cortex-like morphology   Micro-CT   Trabecnlav  
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