河北省肺炎链球菌疫苗在不同年龄组儿童中应用价值分析

目的：根据感染患儿来源的肺炎链球菌血清型分布特征，初步评价不同肺炎链球菌疫苗在相对应年龄组儿童中的应用价值。方法：参考文献对2014年收集到的182株肺炎链球菌菌株提取DNA，应用多重PCR方法进行分型，分析不同疫苗血清型比例。结果：所有菌株中19F和19A型数量最多，分别为68株（占37.36%）和33株（占18.13%），其次较多的型别有6群、35B型、14型、23F型、15B/15C型等。7价、10价、13价肺炎链球菌结合疫苗所含血清型在2岁以下儿童来源菌株中分别占61.33%、61.33%、82.67%。所有2岁以上儿童来源菌株中81.25%属于23价肺炎链球菌多糖疫苗血清型。结论：本研究中肺炎链球菌血清型分布存在以19F、19A型为主同时兼有多样性的特点。针对不同年龄组儿童应用结合疫苗或多糖疫苗都将取得一定的免疫效果。

Application value analysis of Streptococcus pneumoniae vaccine for children of different age groups in Hebei province

Objective Application value of different Streptococcus pneumonia vaccine for the children of corresponding ages was evaluated preliminarily, according to the Streptococcus pneumonia serotype distribution characteristics of sick children. Methods We extracted the DNA from 182 strains of Streptococcus pneumonia collected in 2014, determined the serotypes of them using multiple PCR and analyzed the ratio of different vaccine resume type. Results Among all the strains the most common serotype were 19F (68 strains, 37.36%) and 19A (33 strains, 18.13%), followed by 6 group, 35B, 14, 23F and 15B/15C, et al. The constituent rate of the 7-valent, 10-valent, 13-valent pneumococcal conjugate vaccine serotype were 61.33%, 61.33%, and 82.67% for the children under 2 years, respectively. The 23-valent polysaccharide vaccine covered 81.25% of the strains from children older than 2 years. Conclusions The characteristics of Streptococcus pneumonia serotype distribution in this study were mainly on 19F and 19A, and had the diversity at the same time. The conjugate vaccine and polysaccharide vaccine will both have certain immune effects for children of different age groups.