snoRNA 表达谱与胃癌预后的关联研究

The association between snoRNA profiles and prognosis in patients with gastric cancer

Abstract:Objective To identify snoRNA, which may be related to prognosis of gastric cancer. Methods Ninetygastriccancer patients who diagnosed at Tianjin Medical University Cancer Institute and Hospital were randomly collected in this study,and their clinical data were followed up. A total of 405 snoRNA expression profiles were analyzed in 90 gastric cancer patients.Patients were classified as "low expression" group or "high expression" group according to the median expression of each snoRNAexpression, which was calculated by univariate and multivariate survival analysis. We also screened out the snoRNAs, in whichpatients were survived differently. Patients were classified as high, middle, or low risk groups based on the snoRNA risk score.Values of age, gender, smoking, drinking, histological differentiation (well, moderately-differentiated and poorly differentiated),clinical stage (Ⅰ+Ⅱstage and Ⅲ+Ⅳstage), tumor size (<5 cm and ≥5 cm), tumor location (upper 1/3 and others) and snoRNAisk score (high, middle, and low risk group) were assessed by multivariate Cox analysis. Results There were significantdifferences in overall survival and (or) progression-free survival rates in 19 patients with high and low snoRNAs expressions (P <0.05). Results of multivariate Cox analysis showed that patients with high expression of ACA61， ACA27 and U36A showed a higheroverall survival and progression-free survival rates, while patients with high expression of ENSG00000206898 showed a loweroverall survival and progression-free survival survival rates (P < 0.01). SnoRNA risk score is an independent prognostic factoror patients with gastric cancer. Compared with low risk group, patients in middle risk group and in high risk group showed a shorteroverall survival and progression-free survival rates (P < 0.001). Conclusion The expressions of ACA61, ACA27, U36A andENSG00000206898 are independent prognostic factors of gastric cancer. Low expressions of the first three indexes and highexpressions of the last one predict a bad prognosis.