| DNA免疫研究进展 |
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| 引用本文： | 杨丽琛,杨晓光. DNA免疫研究进展[J]. 卫生研究, 2006, 35(1): 110-114 |
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| 作者姓名： | 杨丽琛 杨晓光 |
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| 作者单位： | 中国疾病预防控制中心营养与食品安全所,北京,100050 |
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| 摘 要： | DNA免疫可诱导机体全面的免疫应答,且与传统的蛋白免疫相比具有制作简单、经济安全、易于贮存运输等优点。自发现以来已越来越引起人们的重视,成为第三代疫苗,并广泛用于各种感染性疾病的防治研究中。作者主要综述DNA免疫作用机理,可能的影响因素,及其在抗体制备、婴儿免疫、粘膜免疫及表达文库免疫等方面的应用。此外,还介绍了增强DNA免疫效果的策略。
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| 关 键 词： | DNA免疫 免疫机制 影响因素 应用 |
| 文章编号： | 1000-8020（2006）01-0110-05 |
| 收稿时间： | 2005-02-24 |
| 修稿时间： | 2005-02-24 |
Study on the development of DNA immunization technique |
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| Yang Li-chen,Yang Xiao-guang. Study on the development of DNA immunization technique[J]. Journal of hygiene research, 2006, 35(1): 110-114 |
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| Authors: | Yang Li-chen Yang Xiao-guang |
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| Affiliation: | Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China |
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| Abstract: | As the third generation of vaccine, DNA immunization seems to be advantageous over classic immunization with purified proteins, which can induce complete immune responses against a number of infectious agents and can be used safely, economically and conveniently. The author reviews the new development of DNA immunization, including parameters affecting its effectiveness, the basic underlying biological mechanisms, and its application on generation of antibodies, infant immunization, mucous membrane immunization, and expression library immunization etc. In addition, we introduce some strategies of improving the effect of DNA immunization. |
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| Keywords: | DNA Immunization biological mechanism affecting factor application |
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