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nm23-H1 expression in squamous cell carcinoma of the head and neck |
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| Authors: | John S. McDonald Peter S Gartside Ljiljana J Pavelic Jack L Gluckman Zlatko P Pavelic |
| Affiliation: | (1) Departments of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio;(2) Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio;(3) Division of Molecular Oncology, Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, 45267-0528 Cincinnati, Ohio, USA |
| Abstract: | Archival material from 47 patients with primary squamous cell carcinoma of the head and neck (SCCHN) was studied immunohistochemically for the presence of nm23-H1 protein. Our data indicate that nm23-H1 protein expression is a common event in SCCHN and that there is a trend toward correlation of increased expression of nm23-H1 with increasing tumor size (p = 0.072). The results also show that when adjusting for age and cause of death, there tended to be an inverse relationship between overall survival and the expression of nm23-H1 gene in the primary tumor (p = 0.088). |
| Keywords: | head and neck cancer nm23-H 1 gene expression immmunohistochemistry prognosis |
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