肝脏常见富血供肿物微血管密度的研究

目的研究肝脏富血供肿物中常见恶性病变肝细胞性肝癌（hepatocellularcarcinoma，HCC）和肝脏良性病变局灶性结节性增生（focalnodularhyperplasia，FNH）、肝腺瘤（hepaticadenoma，HA）CD34显色、微血管密度（microvesseldensity，MVD）的差异及临床意义。方法分别对32例HCC、12例FNH及5例HA组织行CD34免疫组化染色，并对各组CD34显色结果及MVD进行比较分析。结果CD34在HCC、FNH及HA组织中均有不同程度的阳性表达。HCC的MVD为（57．88±24．89）／mm2，低于良性组（FNH、HA）的MVD（112．59±14．56）／ramz，两者MVD比较差异有统计学意义（P〈O．05）。结论CD34作为血管内皮标志物不具有反映恶性肿瘤的特异性。MVD亦不能作为反映肝脏肿物诱导血管新生能力的特异性指标。HCC的MVD低于FNH、HA的MVD，可为影像学鉴别诊断提供病理学基础。

Study of microvessel density in hypervascular hepatic mass

Objective To investigate patterns of CD34 expression and microvessel density （MVD） in hepatocellular carcinoma （HCC）,focal nodular hyperplasia （FNH） and hepatic adenoma （HA）. Methods Samples from patients with HCC （n=32）, FNH （n=12）and HA （n=5）were analyzed by immunohistochemistry using an anti-CD34 antibody.MVD was also measured in all samples. Results CD34 was expressed in all three types of hypervascular hepatic mass.The MVD was significantly lower in HCC than in the benign lessions FNH and HA （P〈O.05）. Conclusions The significantly lower MVD in HCC compared to FNH and HA may allow imaging-based diagnosis of the disease.