| 焦炉工血清p53蛋白的检测分析 |
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| 引用本文： | 贾改珍.焦炉工血清p53蛋白的检测分析[J].滨州医学院学报,2007,30(4):279-280. |
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| 作者姓名： | 贾改珍 |
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| 作者单位： | 滨州医学院卫生统计与流行病学教研室,烟台市,264003 |
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| 摘 要： | 目的 探讨职业接触焦炉逸散物的焦炉工人血清p53蛋白的表达水平及其在肺癌高危人群筛检中的意义.方法 运用蛋白质印迹技术(Westernblot),对接触组118例和对照组50例人群的血清p53蛋白进行检测,比较两组血清p53蛋白的表达水平.结果 接触组不同工龄组、不同作业地点间p53蛋白的表达水平具有统计学意义(P﹤0.05).结论 经常大量接触焦炉逸散物可使p53蛋白的表达水平升高,增加p53基因异常的危险性,从而使焦炉工患肺癌的危险性增加.
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| 关 键 词： | 焦炉逸散物 蛋白免疫印迹 p53蛋白 焦炉工 人血清 蛋白质 检测分析 workers coke oven protein serum 危险性 基因异常 大量接触 统计学意义 作业 龄组 结果 比较 人群筛检 对照组 Westernblot 印迹技术 |
| 文章编号： | 1001-9510（2007）04-0279-02 |
| 收稿时间： | 2007-03-28 |
| 修稿时间： | 2007年3月28日 |
Study on serum p53 protein in coke oven workers |
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| JIA Gaizhen.Study on serum p53 protein in coke oven workers[J].Journal of Binzhou Medical College,2007,30(4):279-280. |
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| Authors: | JIA Gaizhen |
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| Institution: | Department of Epidemiology, Binzhou Medical University, Yantai 264003 |
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| Abstract: | Objective Serum p53 protein overexpression was detect in coke oven workers to explore the biomarker of early diagnosis of lung cancer.Methods Western blot was used for determing the level of p53.Serum p53 were compared between two groups.Results Compared with the control group,p53 levels in the different exposed group and different operating points increased significantly(P<0.05),and the expression of p53 increased gradually in the exposed group with years of service.Conclusion The results suggested that coking oven emissions(COE) were likely to cause mutation of p53 gene and increasing the incidence of lung cancer. |
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| Keywords: | coking oven emissions(COE) Westernblot p53 protein |
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