| 合成聚肽膜渗透抗癌药物的研究 |
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| 引用本文： | 何卫东 方月娥. 合成聚肽膜渗透抗癌药物的研究[J]. 生物医学工程学杂志, 1995, 12(3): 187-190 |
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| 作者姓名： | 何卫东 方月娥 |
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| 作者单位： | 中国科学技术大学材料科学与工程系 |
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| 摘 要： | 本文制备了聚谷氨酸苄酯膜，并进行皂化，得到了谷氨酸苄酯－谷氨酸共聚物膜．研究了不同聚合物膜对两种抗癌药物５－氟脲嘧啶（５Ｆｕ）及２－羟乙基－氧甲基－５－氟脲嘧啶（２－ＨＥＯＭ－５－ＦＵ）的渗透性能。结果表明Ｐ１（ＢＬＧ－ＬＧＡ）膜渗透５－Ｆｕ和２－ＨＥＯＭ－５－Ｆｕ的渗透系数分别是ＰＢＬＧ膜的４和１６倍，且Ｐ２（ＢＬＧ－ＬＧＡ）膜的渗透系数分别是ＰＢＬＧ膜的１３和２６倍．
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| 关 键 词： | 聚谷氨酸苄酯膜 抗癌药物 |
Permeation of Anticancer Drugs through Synthesized Polypeptide Membranes |
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| He Weidong, Fang Yue''e, Shi Tianyi. Permeation of Anticancer Drugs through Synthesized Polypeptide Membranes[J]. Journal of biomedical engineering, 1995, 12(3): 187-190 |
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| Authors: | He Weidong Fang Yue''e Shi Tianyi |
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| Abstract: | The membranes of poly(benzenyl L-glutamate-co-L-glutamic acid ) were prepared by saponitfication of poly(benzenyl L-glutamate) membrane. The permeation of two anti-cancer drugs of 5-fluoro-uracil (5-Fu) and 2-hydroxy-ethyl-oxy-methyl-5-fluoro-uracil (2-HEOM-5-Fu ) through these membranes was studied. The results showed that the permeation coefficients of 5-Fu and 2-HEOM-5-Fu through P1 (BLG-LGA) membrane were 4 and 16 times larger than those of PBLG membrane respectively, and those through P2 (BLG-LGA) membrane were 13 and 26 times larger than those of PBLG membrane respectively. |
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| Keywords: | PBLG membrane P (BLG-LGA ) membrane Anticancer drug Permeation |
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